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p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations |
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| Authors: | Hardie Laura J Darnton S Jane Wallis Yvonne L Chauhan Anita Hainaut Pierre Wild Christopher P Casson Alan G |
| Affiliation: | aNational Lab of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People's Republic of China bDepartment of Thoracic Surgery, the First Affiliate Hospital of Anhui Medical University, Hefei 230022, People's Republic of China |
| Abstract: | Our previous work has shown that a number of genes locating on 1q21 were down-regulated in esophageal squamous cell carcinomas (ESCC) and they may involve in carcinogenesis. To determine whether chromosome 1q LOH occurs in ESCC, we analyzed LOH in 61 ESCCs using 18 microsatellite markers on chromosome 1q. Forty-six of 61 (75.4%) tumors presented LOH at one or more loci. A significant association was found between chromosome 1q LOH and histopathological grade. LOH on D1S3466 had a negative correlation with family history, whereas LOH on D1S2777 positively correlated with smoking. These results suggest this region harbor putative tumor suppressor gene(s) contributing to tumorigenesis and differentiation in ESCC. |
| Keywords: | Allelic imbalance Esophageal squamous cell carcinomas Chromosome 1q |
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