糖尿病患者尿GPDA与血清脂质变化的关系

目的　探讨糖尿病患者尿甘氨酰脯氨酸二肽氨基肽酶 (GPDA)与血清脂质变化的关系。方法　选择糖尿病患者 2 1 1例 ,正常对照组 98名 ,检测尿GPDA和血清脂质的水平 ,对其相互关系进行分析。结果　糖尿病患者组尿GPDA水平显著高于正常对照组 (t=4 .2 5 5 5 ,P <0 .0 0 1 ) ,血清胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL C)、TC/高密度脂蛋白胆固醇比值 (TC/HDL C)、LDL C/HDL C比值、载脂蛋白B(ApoB)、脂蛋白 (a) Lp(a) ]水平均高于正常对照组 (P <0 .0 0 1 ) ,而HDL C、载脂蛋白Al(ApoAl)、ApoAl/ApoB比值则明显低于正常对照组 (P <0 .0 1 )。糖尿病患者分组比较 ,血清TC、TG、LDL C、TC/HDL C、LDL C/HDL C、ApoB、Lp(a)随尿GPDA排泄量增多呈增高趋势 ,而HDL C、ApoAl、ApoAl/ApoB比值呈下降趋势。 结论　糖尿病患者伴有脂代谢紊乱 ,并与尿GPDA的升高、肾功能的损害相平行

The relation between urine glycyl-proline dipeptidyl aminopeptidase and serum lipid in patients with diabetes mellitus

Objective To study the relations between urine glycyl proline dipeptidyl aminopeptidase(GPDA) and serum lipid in patients with diabetes mellitus(DM). Methods The levels of urine GPDA and serum lipid of 211 DM patients and 98 normal controls were detected and the relations between them were analyzed. Results Urine GPDA levels of DM patients were obviously higher than those of healthy control group ( t=4.255 5,P<0.001 ). Cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL C), the ratio of cholesterol and high density lipoprotein cholesterol (TC/HDL C), the ratio of LDL C and HDL C, apolipoprotein B(ApoB), lipoprotein(a)Lp(a)] of DM patients were higher than those of healthy control group( P <0.001). But HDL C, apoliporotein Al(ApoAl) and ApoAl/ApoB of DM patients were lower than those of healthy control group( P <0.01). In DM patient group when the excretion of urine GPDA increased serum TC,TG,LDL C,TC/HDL C,LDL C/HDL C,ApoB and Lp(a) tended to increase, while the serum HDL C,ApoAl and ApoAl/ApoB tended to decrease. Conclusions In DM patients disorder of lipid metabolism accompanied the rising of urine GPDA.