| 抗新型冠状病毒小分子化合物研究进展 |
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| 引用本文： | 徐向荣,姚雷. 抗新型冠状病毒小分子化合物研究进展[J]. 中国药业, 2022, 0(3): 1-8 |
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| 作者姓名： | 徐向荣 姚雷 |
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| 作者单位： | 烟台大学校医院;烟台大学药学院 |
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| 摘 要： | 目的 总结抗严重急性呼吸综合征冠状病毒2(SARS-CoV-2)小分子化合物的研究进展.方法 采用计算机检索SciFinder、PubMed、中国知网、万方、维普等数据库中相关文献,检索时限为2019年1月至2021年3月,中英文关键词为"COVID-19""SARS-CoV-2""small molecule""新型...
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| 关 键 词： | 严重急性呼吸综合征冠状病毒2 小分子化合物 新型冠状病毒肺炎 |
Research Progress on Anti-SARS-CoV-2 Small-Molecule Compounds |
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| XU Xiangrong,YAO Lei. Research Progress on Anti-SARS-CoV-2 Small-Molecule Compounds[J]. China Pharmaceuticals, 2022, 0(3): 1-8 |
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| Authors: | XU Xiangrong YAO Lei |
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| Affiliation: | (Yantai University Hospital,Yantai,Shandong,China 264005;School of Pharmacy,Yantai University,Yantai,Shandong,China 264005) |
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| Abstract: | Objective To summarize the research progress on anti-severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)small-molecule compounds.Methods The related literature in the database such as SciFinder,PubMed,CNKI,WanFang,VIP from January 2019 to March 2021 were retrieved with the keywords of "COVID-19" "SARS-CoV-2" "small molecule"(English) and "SARS-CoV-2"(Chinese).Results The anti-SARS-CoV-2 small-molecule compounds were mainly derived from virtual screening of natural products or synthetic compounds,optimization of lead compounds,artificial intelligence de novo design,and new use of old drugs.Conclusion Through the research on the main structure of virus and the main targets in the process of replication and assembly,the utilization of modern techniques for new drug research will accelerate the research and development of anti-SARS-CoV-2 small-molecule agent. |
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| Keywords: | SARS-CoV-2 small-molecular compounds COVID-19 |
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