羧甲司坦联合氨溴索治疗慢性阻塞性肺疾病临床研究

目的 探讨羧甲司坦联合氨溴索治疗慢性阻塞性肺疾病(COPD)的临床疗效,以及对患者炎性因子和氧化应激指标的影响.方法 选取医院呼吸与危重症医学科2019年1月至2020年12月收治的COPD住院患者100例,按随机数字表法分为观察组和对照组,各50例.两组患者均予氨溴索,观察组患者加用羧甲司坦,均以2周为1个疗程,连续...

Clinical Study of Carbocisteine Combined with Ambroxol in the Treatment of Chronic Obstructive Pulmonary Disease

Objective To investigate the clinical efficacy of carbocisteine combined with ambroxol in the treatment of chronic obstructive pulmonary disease(COPD) and its effect on the inflammatory factors and oxidative stress indexes.Methods A total of100 inpatients with COPD admitted to the Department of Respiratory and Critical Care Medicine in the hospital from January 2019 to December 2020 were selected and divided into the observation group and the control group by the random number table method,with 50 cases in each group.The patients in the two groups were treated with ambroxol,on this basis,the patients in the observation group were treated with carbocisteine.Both groups were treated for three consecutive courses with two weeks as a course of treatment.Results Two cases in the observation group voluntarily withdrew and one case in the control group did not strictly implement the treatment plan,all of them were excluded.The total effective rate of the observation group was 91.67%,which was significantly higher than 73.47% of the control group(P <0.05).After treatment,the levels of tidal volume(TV),vital capacity(VC) and total lung volume(TLC) in the observation group were significantly higher than those in the control group(P <0.05).The levels of monocyte chemoattractant protein-1(MCP-1),Toll-like receptor 4(TLR4) and high-sensitivity Creactive protein(hs-CRP) in the observation group were significantly lower than those in the control group(P <0.05).The levels of 8-hydroxydeoxyguanosine(8-OHdG) and myeloperoxidase(MPO) in the observation group were significantly lower than those in the control group,while the level of glutathione peroxidase(GSH-Px) in the observation group was significantly higher than that in the control group(P <0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(16.67% vs.10.20%,P> 0.05).Conclusion Carbocisteine combined with ambroxol is effective and safe in the treatment of COPD,which can improve the pulmonary ventilation function,reduce the level of inflammatory factors,and improve the oxidative stress response of the body.