利用多次采集计划CT和锥形束CT评价前列腺癌靶区运动相关性

目的:利用多次采集计划CT(MAPCT)和锥形束CT获取前列腺癌患者靶区治疗前和治疗中位移数据,评价治疗前、治疗中靶区各向运动之间相关性,从而为优化靶区计划设计提供数据支持。方法:筛选12例前列腺癌患者,于靶区内植金标记物,接受3次治疗前MAPCT扫描和10次治疗中锥形束CT扫描,利用两种扫描数据评价治疗前、治疗中靶区各向运动相关性。结果:治疗前、治疗中位移在左右、头脚方向上相关性系数R分别为0.559、-0.326,中度,弱相关,结果不具有统计学意义;前后方向R为0.883,强相关,结果具有统计学意义。结论:可以利用治疗前MAPCT预估前后方向上治疗中靶区位移量,从而优化前列腺癌放疗计划。

Evaluating the correlation between pre- and in-treatment target displacements in prostatecancer radiotherapy by multiple acquisition planning CT and cone-beam CT

Objective To evaluate the correlation between the dimensional target displacements before and during treatment for prostate cancer using target displacement data obtained by multiple acquisition planning CT and cone-beam CT,thereby providing some data support for the optimization of treatment planning.Methods Gold implants were implanted in the target areas of 12 prostate cancer patients.Each patient underwent 3 pre-treatment multiple acquisition planning CT scans and 10 intreatment cone-beam CT scans.The correlation of pre-and in-treatment dimensional target displacements was evaluated by the data obtained in scanning.Results The correlation coefficient R of the displacements in left-right and superior-inferior directions before and during treatment was 0.559 and-0.326,respectively,which indicated moderate and week correlations,without statistical significance.However,the correlation in anterior-posterior direction was relatively strong and statistically significant,with the coefficient R of 0.883.Conclusion Pre-treatment multiple acquisition planning CT can be used to predict the in-treatment target displacements in anterior-posterior direction,thereby optimizing the radiotherapy plan of prostate cancer.