冠心病心绞痛患者血清脂联素水平的改变及临床意义

目的观察临床心绞痛（AP）病人血清脂联素水平的变化,并探讨其临床意义。方法选取AP病人62例,其中稳定型心绞痛（SAP）25例,不稳定型心绞痛（UAP）37例,以正常健康人28例为正常对照组。所有研究对象均测定血压、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高敏C-反应蛋白（hs-CRP）和血清脂联素水平。结果 AP患者的血压、TG、TC、LDL-C、hs-CRP和血清脂联素水平均较正常对照组明显升高（P〈0.05）。UAP组和SAP组对比,血压、TG、TC、LDL-C差异无统计学意义,但是UAP组患者的hs-CRP和血清脂联素水平明显高于SAP组（P〈0.05）。AP患者的脂联素与hs-CRP水平有良好的正相关性（r=0.331,P〈0.05）。结论脂联素在AP的发病中起着重要的作用,可以作为临床AP严重程度的重要实验室指标。

The change of serum concentrations of adiponectin in patients with angina pectoris

Objective To observe the serum concentrations of adiponectin in patients with angina pectoris（AP）and explore its clinical significance.Methods Sixty-two AP patients were divided into stable AP group（SAP,n=25） and unstable AP group（UAP,n=37）,and 28 healthy subjects were selected as control group.The indicators of blood pressure（BP）and the levels of triglycerides（TG）,total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,high sensetivity C-reactive protein（hs-CRP） and adiponectin in each groups were tested.Results Compared to those in the control group,the levels of BP、TG、TC、LDL-C、hs-CRP and adiponectin in AP patients were significantly higher（P0.05）.The concentrations of adiponectin and hs-CRP in the UAP group were higher than those in the SAP group although that of BP,TG,TC and LDL-C showed no significant difference between the SAP group and the UAP group,The concentration of adiponectin showed positive correlation（r=0.331,P0.05） to that of hs-CRP in the AP patients.Conclusion Adiponectin may play an important role in the pathogenesis of AP,and it can be used to judge the severity of AP.