MODS患者血清铜蓝蛋白测定的意义

目的探讨血清中铜蓝蛋白动态变化对多器官功能障碍综合症（MODS）患者早期诊断和病因判断的价值。方法于入院当天分别检测60例MODS患者（MODS组）、30例非MODS患者（对照组）血清铜蓝蛋白（CP）、超敏C反应蛋白（CRCP）、α-酸性糖蛋白（AAG）的含量,并对入选的住院患者进行APACHEⅡ和MODS评分。结果MODS组与对照组相比其APACHEⅡ、MODS评分、血清铜蓝蛋白（CP）、超敏C反应蛋白（CRCP）、α-酸性糖蛋白（AAG）的比较,差异有统计学意义（P〈0.05）。非感染组与感染组相比较,铜蓝蛋白与超敏C反应蛋白均明显升高,差异有统计学意义（P〈0.05）。结论 MODS患者铜蓝蛋白、超敏C反应蛋白、α-酸性糖蛋白的检测有助于MODS早期诊断;铜蓝蛋白及超敏C反应蛋白的监测有助于MODS病因的初步判断。

Significance of detection of serum ceruloplasmin in diagnosis of MODS patients

Objective To investigate the significance of dynamic changes of serum ceruloplasmin in multiple organ dysfunction syndrome（MODS）for early diagnosis and treatment of the cases.Methods The levels of serum ceruloplasmin（CP）,high-sensitivity C-reactive protein（CRCP）,α-acid glycoprotein（AAG in 60 MODS patients,MODS group）on the day of admission and 30 cases of non-MODS patients（control group）were determined and analyzed.The APACHE Ⅱ,MODS score were compared between two groups.Results The APACHE Ⅱ,MODS score,based on the levels of serum ceruloplasmin,high-sensitivity C-reactive protein and α-acid glycoprotein in MODS group were significantly different compared to the control group（P0.05）.Compared with non-infection group,ceruloplasmin and C-reactive protein were significantly increased,the difference was significant（P0.05）.Conclusion In MODS patients,ceruloplasmin and C-reactive protein test can help early diagnose the syndrome;ceruloplasmin and C-reactive protein monitoring also can help determine the cause of MODS useful for guiding treatment of MODS patients.