生长分化因子GDF-15与心血管疾病

生长分化因子（GDF-15）属于生长分化因子家族,是转化生长因子β超家族成员之一。它是一种有心脏保护性能的生物因子,能抑制心肌细胞的肥大、心肌重塑和细胞凋亡。在心肌缺血-再灌注损伤、氧化应激反应、炎症因子和压力过载的情况下GDF-15浓度迅速增大,为急性冠脉综合征、心力衰竭和肺栓塞提供短期或长期独立的预后信息。它是冠心病患者的危险分层和治疗决策的潜在新标志物。

Correlation of GDF-15 with cardiovascular disease

Growth differentiation factor-15（GDF-15）which belongs to the GDF family is a member of TGF-β super family.It is a cytokine with cardioprotective properties,capable of inhibiting hypertrophy,cardiac remodeling and apoptosis.The concentration of GDF-15 would rapidly increase under the condition of ischemia-reperfusion damage to heart muscle,oxidative stress,inflammatory cytokines and pressure overload.In patients with acute coronary syndromes,heart failure and pulmonary embolism provides independent prognostic information,both short-and long-term.It is potentially a new marker of risk stratification in patients with heart disease and therapeutic decision making.