急性胰腺炎患者凝血指标与糖尿病相关指标的探讨

目的探讨急性胰腺炎患者入院时凝血、纤溶相关指标与出院后血浆糖化血红蛋白（HbAlc）及C肽水平的相关性。方法入选2007年6月～2009年12月在普外科住院治疗的急性胰腺炎患者56例和同期门诊健康体检者非急性胰腺炎30例,检测所有实验对象血浆PT、APTT、FIB、D二聚体及出院后HbAlc及C肽水平,对AP患者入院时凝血、纤溶相关指标与出院3月后HbAlc及C肽水平进行Pearson直线相关分析。结果与对照组比较,AP患者血浆PT、APTT及D二聚体明显升高,两组间差异有统计学意义（P〈0.05）;AP患者入院时凝血、纤溶相关指标与出院3月后HbAlc及C肽水平存在相关性。结论 AP患者入院时血浆PT、APTT及D二聚体与出院3月后HbAlc正相关,与出院3月后血浆C肽水平呈负相关;提示AP组患者入院时血浆PT、APTT及D二聚体水平可能能预测AP患者出院后糖尿病的发生。

Correlation of coagulation-related parameters with occurrence of diabetes in patiens with acute pancreatitis

Objective To investigate the correlation of coagula ion-related parameters with occurrence of diabetets in patients with acute pancreatitis.Methods A total of 56 patients with acute pancreatitis and 30 healthy people were recruited in this study.The indicators of prothrombin time（PT）,activated partial thrombin time（APTT）,the levels of blood fibrinogen（FIB）,D-dimer,serum glyocosylated HbA1c and C-peptide in patients with acute pancreatitis at the time of admission and in the healthy controls were measured and compared with that of the patients determined three months before discharged.Results The indicators of PT,APTT and levels of D-dimer and glyocosylated HbA1c were significantly increased in comparison with that of the Controlgroup（P0.05）.The indicators of PT,d APTT and level of D-dimer were correlated with the levells of glyocosylated HbA1c and C-peptide in patiens with acute pancreatitis.Conclusions The indicators of PT,APTT and level of D-dimer in acute pancritits pattients at the time of admission are positively correlated with the level of glyocosylated HbA1c three month later at the time of discharge,but they are negatively correlated with the C-acute pancreatitis,suggesting that determination of indicators of PT,APTT and level of D-dimer in acute pancreatitis patients at the time of admission can predict the occurrence of diabetes.