狂犬病165例临床分析

目的总结狂犬病临床特征及流行病学表现,提出相应的防治对策。方法对165例狂犬病患者个案进行流行学调查,并进行回顾性分析。结果患者以农民为主,占80%,男129例,女36例,年龄3～82岁,96%病例有典型狂犬病症状,99%患者中性粒细胞升高,78%血糖升高,潜伏期12d～20余年;从发病到死亡时间1～10d。88%患者未正确处理伤口,84.8%的患者暴露后未接种狂犬疫苗。结论联合抗病毒治疗并早期使用人工呼吸机辅助呼吸对延长患者生存期有一定意义,对患者暴露后及时正确伤口处理,按时、全程主动免疫联合被动免疫是降低发病率的重要措施。

Clinical analysis of 165 rabies patients

Objective To observe the clinical and epidemiological features and of rabies patients.Methods Epidmemiological survey of 165 rabies patients were and retrosopectively analyzed.Results The majority of the patients aged 3-82 years were peasants,accounting for 80%.There were 129 male cases（78%）and 36 female cases（22%）.Furthermore,96% of the patients had typical symptoms of rabies.The number of eutrophilic granulocyte increased significantly in 99% and elevatio of blood sugar level was noticed in 78% of them.The incubation period lasted from 12 days to more than 20 years before the symptoms of rabies manifested;while the duration of from onset to death was within 10 days.The wounds of 88% of the patients were not properly treated and 84.8% of the patients were not inoculated with rabies vaccine after exposure.Conclusion Currently there is no effective treatment for rabies patients.Using artificial respirator in the early stage combined with antiretroviral therapy is of certain significance in extending patients＇life,but propere treatment of the wounds and use of rabes vaccine in full course are the essential measures.