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| 复方巴戟天合剂对大鼠激素性股骨头缺血性坏死的组织学研究 | |
| 引用本文： | 孙克民,王和鸣,陈文列,黄美雅. 复方巴戟天合剂对大鼠激素性股骨头缺血性坏死的组织学研究[J]. 湖南中医药大学学报, 2011, 31(7): 14-17. DOI: 10.3969/j.issn.1674-070X.2011.07.004.014.04 |
| 作者姓名： | 孙克民 王和鸣 陈文列 黄美雅 |
| 作者单位： | 1. 广东省深圳平乐骨伤科医院,广东深圳,518010 2. 福建中医药大学,福建福州,350108 3. 福建中西医结合研究院重点实验室,福建福州,350108 |
| 基金项目： | 国家自然科学基金资助项目(30271630) |
| 摘 要： | 目的探讨复方巴戟天合剂对激素性股骨头缺血性坏死大鼠股骨头的组织学影响。方法 SD大白鼠72只,随机分成正常组、模型组、对照组、治疗组,每组18只。建立大鼠激素性股骨头缺血性坏死模型,对照组、治疗组每日给药1次,于实验后第4、8、12周分3批处死动物,取股骨头空骨陷窝、成骨细胞、破骨细胞及胶原面积进行统计学分析。结果空骨陷窝率模型组与正常组差异有统计学意义(P<0.01),治疗组与对照组较模型组差异有统计学意义(P<0.01);治疗组与对照组成骨细胞计数较模型组差异有统计学意义(P<0.01),破骨细胞计数较模型组差异有统计学意义(P<0.01);治疗组与对照组胶原面积百分比与模型组比较差异有统计学意义(P<0.01)。结论复方巴戟天合剂对激素性股骨头缺血性坏死有明显的预防和治疗作用。 |
| 关 键 词： | 复方巴戟天合剂 股骨头坏死 组织学 实验研究 大鼠 巴戟天 淫羊藿 骨碎补 |
Effects of compound Morinda mixture on histological changes in rats with glucocorticoid-induced avascular necrosis of femoral head |
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| SUN Ke-min,WANG He-ming,CHEN Wen-lie,HUANG Mei-ya. Effects of compound Morinda mixture on histological changes in rats with glucocorticoid-induced avascular necrosis of femoral head[J]. Journal of Traditional Chinese Medicine University of Hunan, 2011, 31(7): 14-17. DOI: 10.3969/j.issn.1674-070X.2011.07.004.014.04 | |
| Authors: | SUN Ke-min WANG He-ming CHEN Wen-lie HUANG Mei-ya |
| Affiliation: | SUN Ke-min,WANG He-ming,CHEN Wen-lie,HUANG Mei-ya(Shenzhen Pingle Orthopaedic Hospital,Shengzhen,Guangdong,518010,China) |
| Abstract: | Objective To observe the effects of compound Morinda mixture on histological changes in rats with glucocorticoid-induced avascular necrosis of the femoral head(ANFH).Methods Seventy two rats were randomly divided into normal group,model group,control group and therapeutic group,18 rats each group.The rat models were established by injection of glucocorticoid.The rats were given drugs by gastric infusion one time a day and were killed in the fourth,eighth and twelfth week respectively.Then the histology chan... |
| Keywords: | compound Morinda mixture osteonecrosis of femoral head histology experimental research rats Morinda Epimedium Drynaria |
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