| 敬钊毒素-V对吗啡成瘾小鼠戒断症状的影响 |
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| 引用本文： | 徐德宏,陈仁忠,池宇朋,蔡丽君,文宁,肖玉成,王贤纯,曾雄智,梁宋平.敬钊毒素-V对吗啡成瘾小鼠戒断症状的影响[J].湖南中医药大学学报,2011,31(7):11-13. |
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| 作者姓名： | 徐德宏 陈仁忠 池宇朋 蔡丽君 文宁 肖玉成 王贤纯 曾雄智 梁宋平 |
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| 作者单位： | 1. 湖南师范大学蛋白质化学与发育生物学教育部重点实验室,湖南长沙,410081
2. 湖南中医药大学,湖南长沙,410208 |
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| 基金项目： | 国家973项目(2009CB526510,2010CB529800); 863项目(2006AA02Z141); 湖南省自然科学基金资助项目(07JJ3072); 教育部新世纪优秀人才支持计划(NCET-07-0279)资助; 湖南省教育厅重点项目(OTA035) |
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| 摘 要： | 目的观察Jingzhaotoxin-V敬钊毒素-V(JZTX-V)对纳洛酮催促戒断症状的治疗作用。方法建立吗啡成瘾小鼠模型,分别测定4组不同剂量5,50,500,1000μg/kg JZTX-V对小鼠戒断后跳跃次数的影响。结果 JZTX-V在戒断后的15min内能减少小鼠的跳跃次数,而且5、50和500μg/kg JZTX-V对跳跃次数的抑制具有统计学意义(P<0.05、P<0.01)。结论 JZTX-V在5-500μg/kg范围内能显著抑制小鼠戒断后的跳跃次数,有可能成为一种戒毒先导分子。
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| 关 键 词： | 敬钊毒素-V 吗啡依赖 戒断症状 纳洛酮 小鼠 |
Effects of JZTX-V on withdrawl symptoms in morphine dependent mice |
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| XU De-hong,CHEN Ren-zhong,CHI Yu-peng,CAI Li-jun,WANG Xian-chun,ZENG Xiong-zhi,LIANG Song-ping.Effects of JZTX-V on withdrawl symptoms in morphine dependent mice[J].Journal of Traditional Chinese Medicine University of Hunan,2011,31(7):11-13. |
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| Authors: | XU De-hong CHEN Ren-zhong CHI Yu-peng CAI Li-jun WANG Xian-chun ZENG Xiong-zhi LIANG Song-ping |
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| Institution: | XU De-hong,CHEN Ren-zhong,CHI Yu-peng,CAI Li-jun,WANG Xian-chun,ZENG Xiong-zhi,LIANG Song-ping(Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education,Hunan Normal University,Changsha,Hunan,410081,China) |
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| Abstract: | Objective To observe the treatment effects of Jingzhaotoxin-V(JZTX-V) on withdrawl symptoms aroused by Naloxone precipitation.Methods The mice models with morphine addiction were divided in 5,50,500 and 1000 μg/kg JZTX-V groups and each dose affected on the jumping times of mice after withdrawl.Results The JZTX-V reduced the jumping times of mice during the 15 minutes after withdrawl,and the doses 5,50 and 500 μg/kg JZTX-V were significant to inhibit the jumping times(P<0.05 and P<0.01).Conclusion When the doses between 5 and 500 μg/kg,JZTX-V can significantly reduce jumping times of mice after withdrawl,which may be a leading molecule to be getting rid of drugs. |
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| Keywords: | JZTX-V morphine dependence withdrawl symptom naloxone mice |
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