急性多发性神经根神经炎外周血T淋巴细胞亚群的研究

用抗人T细胞单克隆抗体OKT_3、OKT_4,OKT_8检测急性多发性神经根神经炎(AP)患者T淋巴细胞细胞亚群。共检测AP患者23例,正常对照20例,并观察不同病情、病型患者的T细胞亚群的改变。结果表明AP患者OKT_a~+、KT_4~+细胞百分率与正常对照组相同,但OKT_8~+细胞百分率明显低于对照组(P<0.05),OKT_4~+/OKT_a~+细胞比率相应升高(P

Study of T Lymphocyte Subsets in Acute Polyradiculoneuritis

Ficol-Hypaque separated peripheral bloo dmononuclear cells were analysed by indirect immunofluorescence assay with ortho monoclonal antibodies to T cells (OKT₃⁺), helper cells (OKT₄⁺) and suppressor cytotoxic cells (OKT₈⁺). 20 normal subjects and 23 patients with acute polyradiculoneuritis (AP) wore studied, The percentages of OKT₃⁺ and OKT₄⁺ cells were similar in the 2 groups, but the percentages of OKT₈⁺ cells was reduced to 18.96±4.24 compared with 22.28±3.15 in the the normal subjects (p <0.05). The ratio of OKT₄⁺/OKT₈⁺ cells was correspondingly increased to 2.38±0.55, compared with 1.97±0.20 in the normal subjects. These changes fell towards normal with the passage of time. The result suggests that AP might be an autoimmunity disease with cell immunity disorders.