铜陵厂矿地区HP感染情况及与胃肠道疾病关系的探讨

目的：了解铜陵厂矿地区幽门螺杆菌（HP）感染情况及其与消化道疾病的关系。方法：对铜陵厂矿地区18岁以上共1076人进行分层、整群、随机抽样，进行微量胶囊14^C尿素呼气试验、血清学技术和产细胞毒素幽门螺杆菌抗体试验（cagA-HP）检查，再抽取一部分阳性病人进行胃镜检查。结果：14^C尿素呼气试验、血清学检查阳性721人，占67．0％，其中48．5％CagA-HP阳性。对HP影响因子由大到小依次为工作环境、消化道症状、既往史、职业、年龄、接触史、性别和不良生活习惯。结论：铜陵厂矿地区HP感染率稍高于我国普通人群，CagA阳性菌稍低于我国普通人群中感染率；HP感染大多与不良工作环境和生活习惯有关。

The Endemiology of Helicobacter Pylorus Infection and Gastro-Intestinal Disease in Mine and Related Factory Workers of Tong-Ling City, Anwhei

Objective To investigate the endemiology of H.pylorus infection and related gastro-intestinal disease in mine and factory workers of Tong-Ling area.Methods ~(14)C-urea breath test,serum IgG and cytotoxin-producing H.pylorus antibodies determinations were performed in 1076 randomly selected adults among the mine and related factory workers in Tong-Ling area.Gastroscopy was done in 156 subjects(cytotoxin-producing H.pylorus antibody CagA-HP positive 108 and Cag-HP negative 48).Results Seven hundred and twenty-one subjects of the 1076(67.0%) examined were positive with the ~(14)C-urea breath and serological tests,among which 350(48.5% of the 721) were Cag-HP positive.Factors affecting positiveness of HP infection were in the orden of: working environment,gastro-intestinal symptoms,past history,vocation,age,history of previous contact,sex and non-hygienic life-style.Conclusion The HP infection rate in Tong-Ling area was slightly higher that nationwide but with a lower CagA-HP positive rate.HP infection was mostly related to the working environment and life-style.