经腹子宫切除术术式对阴道免疫防御功能的影响

目的:探讨开腹子宫切除术术式对阴道免疫防御功能的影响,为临床恰当选择经腹子宫切除术术式提供参考。方法:经腹子宫切除术99例分为研究组(37例,次全子宫切除术)和对照组(62例,全子宫切除术),检测其术前及术后1个月阴道分泌物中免疫因子(SIgA、IL-2、-10)含量及病原微生物。结果:两组术后阴道分泌物中免疫因子含量明显下降(P<0.01),对照组下降更明显(P<0.05)。两组术后外阴阴道假丝酵母菌检出率分别为12.1%和39.6%,细菌性阴道病3.0%和18.8%。研究组阴道炎症发生比例明显低于对照组(P<0.05)。结论:经腹全子宫切除术后患者阴道免疫防御功能易受损而发生阴道炎症。

Effects of Abdominal Hysterectomy on Function of ImmuneDefenses of the Vagina

Objective： To investigate the effect of abdominal hysterectomy on function of immune defense of the vagina, and to find appropriate choice of abdominal hysterectomy. Methods： Ninety-nine patients who accepted abdominal hysterectomy were divided into study group （37 cases, accepted abdominal subtotal hysterectomy）and control group （62 cases, accepted abdominal total hysterectomy）. The concentrations of immune factors （SIgA, IL-2, -10） and pathogens were assayed before operation and one month after operation. Results： The concentrations of immune factors in vaginal discharge decreased significantly between two groups after operation （P〈0.01）, the decrease in the control group was obvious （P〈0.05）. The ratio of Vulvovaginal candidiasis between two groups after operation was 12.1% and 39.6%, 3.0% and 18.8% of bacterial vaginosis respectively. The vaginitis in the study group was less than that in the control group（P〈0.05）. Conclusion： The patients accepted abdominal total hysterectomy is easily impaired in the function of immune defenses of the vagina, but suffering from vaginitis.