Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients |
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Authors: | Davide Seripa Giulia Paroni Maria G Matera Carolina Gravina Carlo Scarcelli Michele Corritore Luigi P D??Ambrosio Maria Urbano Grazia D??Onofrio Massimiliano Copetti Patrick G Kehoe Francesco Panza Alberto Pilotto |
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Institution: | Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy. |
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Abstract: | The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients. |
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Keywords: | Angiotensin-converting enzyme Disability Aging Hospitalized patients |
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