| 黄芩甙大鼠小肠吸收的研究 |
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| 引用本文： | 毛凤斐,屠锡德,朱家璧,赵陆华,胡珍泽. 黄芩甙大鼠小肠吸收的研究[J]. 中国药科大学学报, 1984, 0(1): 61-66 |
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| 作者姓名： | 毛凤斐 屠锡德 朱家璧 赵陆华 胡珍泽 |
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| 作者单位： | 南京药学院药剂学教研室，南京药学院药剂学教研室，南京药学院药剂学教研室，南京药学院药剂学教研室，南京药学院药剂学教研室 |
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| 摘 要： | 本文作者对文献介绍的大鼠在体小肠回流实验装置进行了改进,并用来研究黄芩甙的吸收情况和胆管结扎与不结扎对黄芩甙吸收的影响。胆管结扎与不结扎的药动学参数为:平均吸收半衰期分别是15.45h~(-1)、11.42h~(-1)。最终吸收程度依次是24.44%,31.58%。经方差分析两者无显著差异(F<5.3)。
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| 关 键 词： | 黄芩甙 在体吸收 回流装置 |
ABSORPTION OF BAICALIE IN SMALL INTESTINE OF RAT |
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| Mao Fengfei,Tu Xide,Zhu Jiabi,Zhao Lvhua and Hu Zhenze. ABSORPTION OF BAICALIE IN SMALL INTESTINE OF RAT[J]. Journal of China Pharmaceutical University, 1984, 0(1): 61-66 |
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| Authors: | Mao Fengfei Tu Xide Zhu Jiabi Zhao Lvhua Hu Zhenze |
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| Affiliation: | Department of Pharmaceutics |
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| Abstract: | An improved circular system for rat small intestine in situ was used to de-termine the absorption of baicalin.The result demonstrated a lower absorption-(20-40%).A comparision was made between the absorption with fastened and unfa-stened bile tracts in rats.The pharmacokinetic parameters were as follows:mean(t1/2)a 15.45 h~(-1),11.42 h~(-1),and total absorption,24.44%,31.58%,respectively.Statistcally,no marked difference was observed(variance analysis F<5.3). |
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| Keywords: | Eaicalin The absorption in situ Circular system. |
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