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Effects of alprazolam and imipramine on parasympathetic cardiac control in patients with generalized anxiety disorder |
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| Authors: | Daniel R. McLeod Rudolf Hoehn-Saric Stephen W. Porges Wesley D. Zimmerli |
| Affiliation: | (1) Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205 Baltimore, MD, USA;(2) Institute for Child Study, University of Maryland, 3304 Benjamin Building, 20742 College Park, MD, USA |
| Abstract: | A noninvasive measure was used to assess the effects of alprazolam, imipramine and placebo on parasympathetic (vagal) cardiac control following 6-weeks of medication in patients with generalized anxiety disorder. Flexible dosage at therapeutic levels resulted in increased heart rate and blood pressure and in decreased cardiac vagal control in patients receiving imipramine but not alprazolam or placebo. About 50% of the variance in heart rate changes and changes in mean arterial blood pressure following treatment with imipramine could be accounted for by changes in cardiac vagal control. Decreased cardiac vagal control can now be added to the list of cardiovascular changes seen following several weeks of treatment with imipramine. |
| Keywords: | Imipramine Alprazolam Heart rate Blood pressure Cardiac vagal control Respiratory sinus arrhythmia Human subjects Generalized anxiety disorder |
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