| 血卟啉单甲醚对SD大鼠的致畸学研究 |
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| 引用本文： | 贺清玉 印木泉. 血卟啉单甲醚对SD大鼠的致畸学研究[J]. 第二军医大学学报, 1991, 12(4): 356-358 |
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| 作者姓名： | 贺清玉 印木泉 |
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| 作者单位： | 第二军医大学训练部特殊毒理学教研室 200433(贺清玉，印木泉，陈耀富，蔡东联，王静)，第二军医大学训练部特殊毒理学教研室 200433(毕洁) |
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| 摘 要： |
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| 关 键 词： | 血卟啉单甲醚 生长毒性 致畸学 |
A Teratological Study of Sprague-Dawley Rats with 3 (or 8)-(l-Methoxyethyl)-8 (or 3)-hydroxyethyl-deuteroporphyrin |
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| He Qingyu,Yin Muquan,Chen Yaofu,Cai Donglian,Wang Jing,Bi Jie. A Teratological Study of Sprague-Dawley Rats with 3 (or 8)-(l-Methoxyethyl)-8 (or 3)-hydroxyethyl-deuteroporphyrin[J]. Former Academic Journal of Second Military Medical University, 1991, 12(4): 356-358 |
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| Authors: | He Qingyu Yin Muquan Chen Yaofu Cai Donglian Wang Jing Bi Jie |
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| Abstract: | The potential embryotoxicity, developmental toxicity and teratogenic effects of (3 or 8)-(l-methoxyethyl)-8 (or3)-hydroxyethyl-deuteroporphyrin (PsD-044) were investigated in Sprague-Dawley rats with the conventional teratological method in vivo. According to the recommending clinical dosage, PsD-044 was administered intravenously at 20, 10 and 5mg/kg, as compared to the negative control with saline and the positive control with sodium pentachlorophenolate, respectively on the 10th day of the gestation. Eighty-one pregnant rats and 803 fetuses were examined. The results suggest that the maternal toxicity, embryotoxicity and teratogenic effects of PsD-044 were not found, however, the malformation induced by known teratogen was as high as 14.1%. |
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| Keywords: | PsD-044 embryotoxicity developmental toxicity teratogenic effects rats |
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