咪达唑仑用于重症监护患者镇静的效果评价

目的观察咪达唑仑在重症监护患者中的镇静效果。方法选择2010年1月至2011年12月收治的重症监护患者100例,给予药物镇静治疗,将患者随机分成两组,各50例。对照组给予异丙酚镇静治疗,治疗组给予咪达唑仑镇静治疗,观察两组患者镇静起效时间、达到满意深度时间、苏醒时间及镇静前后与镇静期间心率、平均动脉压、脉搏氧饱和度变化。结果治疗组镇静起效时间、达到满意深度时间、苏醒时间与对照组相比,差异有统计学意义(P<0.05);治疗组心率、平均动脉压、脉搏氧饱和度变化小于对照组,差异有统计学意义(P<0.05)。结论咪达唑仑对重症监护患者有较好的镇静效果,对心血管及呼吸循环抑制轻微,是重症监护患者理想的镇静剂。

Efficacy Evaluation of Midazolam for Sedation in Intensive Care Patients

Objective To investigate the sedative effect of midazolam for intensive care patients. Methods A hundred cases intensive care patients in our hospital from 2010 to 2011 were gaven the drug sedation, these patients were randomly divided into two groups, each group had 50 cases, the control group was given propofol sedation, the treatment group were gaven the microphone to midazolam sedation, the sedation onset time, satisfactory depth of time, recovery time, and calm before and after the sedation during the heart rate, mean arterial blood pressure, pulse oxygen saturation of two groups of patients were observed. Results The sedation onset time, achieve satisfactory depth of time, wake time difference of treatment group was statistically significant（P〈0.05） compared with control group; the heart rate, mean arterial blood pressure, pulse oxygen saturation of treatment group was less than the control group, the difference had statistically significant（P 〈0. 05）. Conclusion The microphone midazolam sedation in intensive care patients have a better effect, a slight inhibition on cardiovascular, respiratory and circulatory, it＇s ideal sedative for intensive care patients.