二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕的疗效评价

目的观察二甲双胍联合克罗米芬治疗多囊卵巢综合征所致不孕的临床疗效。方法选取2010年1月至2012年1月收治的多囊卵巢综合征患者72例,按随机数字表法分为观察组38例采用二甲双胍联合克罗米芬治疗,对照组34例给予克罗米芬治疗。治疗3个周期后,分别检测两组促卵泡激素(FSH)、空腹胰岛素(FINS)、促黄体激素(LH)、空腹血糖(FPG)、睾酮(T);两组排卵率、妊娠率及早孕流产率及内膜厚度。结果观察组与对照组FSH,FINS,T水平比较,差异有统计学意义(P<0.05);两组妊娠率、内膜厚度比较,差异有统计学意义(P<0.05)。结论二甲双胍与克罗米芬治疗多囊巢综合征不孕症患者具有改善激素水平,提高妊娠率及增加子宫内膜厚度的作用,二甲双胍联合克罗米芬治疗多囊卵巢综合征值得临床进一步应用。

Efficacy of Metformin Combined with Clomiphene in the Treatment of Polycystic Ovary Syndrome

Objective To investigate the the efficacy of metfornin combined with clomiphene in the treatment of polycystic ovary syndrome（PCOS）. Methods We analyzed 72 cases who had PCOS,72 cases were randomly divided into 2 groups of 34 case in experimental group who had given clomiphene, and 38 cases in the control group who had given metformin combined with clomiphene. Contrast the level of FSH, FINS, LH, FPG,T,and ovulation rate, pregnancy rate, early abortion rate and thickness of the lining of tow groups. Results The level of FSH, FINS, T were significant difference between two groups（ P 〈 0.05）. The level of LH, FPG were no significant difference（ P〉 0.05）. There were significant difference of pregnancy rate and thickness of the lining（ P 〈0.05） between two groups. There were no significant difference of ovulation rate and abortion rate. Conclusion Metformin and clomiphene treat PCOS infertility can improve the hormone level,increase pregnancy rate and increased endometrial thickness of the role that metformin and comiphene treat PCOS is worth further clinical application.