蛛网膜下腔出血对脑脊液循环影响的仿真模型研究

目的：建立发生蛛网膜下腔出血（SAH）时颅内压（ICP）的变化对脑脊液吸收阻力（Ro）和颅内顺应性（Cic）影响的数学模型并进行仿真。方法：建立一种新的脑脊液循环动力学模型,通过拟合前人动物实验测得的ICP,仿真Ro和Cic随ICP的变化。结果：随ICP增高至最大时Ro增大到最大值,当ICP降低时Ro随之减小,两者成正比关系;Cic随ICP的升高减小,两者成反比关系。结论：该模型能较好地模拟ICP与Ro和Cic的关系,符合SAH病理生理上的一般结论,这将对研究SAH后病理生理学机制提供一定的参考。

Numerical Simulation on How Subarachnoid Hemorrhage Affects Cerebrospinal Fluid Circulation

Objective To build a mathematical model and carry out relevant simulation on how intracranial pressure will affect CSF absorption resistance（Ro） and intracranial compliance（Cic） when subarachnoid hemorrhage occurs.Methods A new CSF dynamics model was developed and the changes of Ro and Cic with ICP was simulated.Results There exists a positive correlation between ICP and Ro：with ICP reaching to the peak value,Ro raised to the maximum and vice versa;and a negative correlation between ICP and Cic：with ICP raising,Cic decreased and vice versa.Conclusion The new model can simulate the relationship between Ro,Cic and ICP better,which has certain referential values for study on pathophysiological mechanisms of SAH.