| 吲哚拉新(Indolacin)的药理研究 |
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| 引用本文： | 袁文学,钱涛,邢春生. 吲哚拉新(Indolacin)的药理研究[J]. 沈阳药科大学学报, 1986, 0(2) |
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| 作者姓名： | 袁文学 钱涛 邢春生 |
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| 作者单位： | 辽宁省药物研究所，辽宁省药物研究所，辽宁省药物研究所 |
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| 摘 要： | 吲哚拉新灌胃给药,对角叉菜胶所致大鼠踝关节肿胀具有抑制作用,其 ED_(50)为11.6±6.0mg/kg,对醋酸所致小鼠扭体反应具有抑制作用,其 ED_(50)为111.7±18.1mg/kg。吲哚拉新腹腔注射30mg/kg,对四联菌苗所致家兔体温升高具有降低作用。吲哚拉新灌胃给药80mg/kg 和100mg/kg,对部分大鼠有致胃溃疡作用;同时灌胃给予白芨—甘草和角叉菜胶,剂量均为1600mg/kg,均有抗吲哚拉新致胃溃疡作用。
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| 关 键 词： | 吲哚拉新 角叉菜胶 抗炎 镇痛 解热 致胃溃疡 白芨—甘草 抗溃疡 |
STUDIES ON PHARMACOLOGICAL ACTIONS OF INDOLACIN |
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| Yuan Wenxue Qian Tao Xing Chunsheng Liaoning Institute of Materia Medica. STUDIES ON PHARMACOLOGICAL ACTIONS OF INDOLACIN[J]. Journal of Shenyang Pharmaceutical University, 1986, 0(2) |
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| Authors: | Yuan Wenxue Qian Tao Xing Chunsheng Liaoning Institute of Materia Medica |
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| Affiliation: | Yuan Wenxue Qian Tao Xing Chunsheng Liaoning Institute of Materia Medica |
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| Abstract: | Experiments in this paper proved that indolacin showed antiinflammatory aetion,analgesic action,and antipyretie action.Its LD_(50) is 1395±232mg/kg po in mice.The ED_(50) of anti-inflammatory action,and analgesic action are 11.6±6.0mg/kg,and 111.7±18.1mg/kg respectively,Indolacin produced gastric ulcers in rats.This effect of indolaein is less than indomethacin.Some drugs such as carrageenin,and Chinese traditional medicine,Ganeao Baiji,prevented gastric ulcers in rats. |
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| Keywords: | Indolacin Carrageenin Anti-inflammation Analgesia Antipyresis Ulceration Bletilla-glycyrrhiza Anti-gastric-ulcer |
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