CXCR4在大肠腺癌中的表达及临床意义 |
| |
引用本文: | 秦晓静,展晓红 时丽芳,郑淑芳.CXCR4在大肠腺癌中的表达及临床意义[J].实用检验医师杂志,2012,4(2):79-83. |
| |
作者姓名: | 秦晓静 展晓红 时丽芳 郑淑芳 |
| |
作者单位: | 秦晓静 (300162天津市,武装警察部队后勤学院附属医院病理科) ; 展晓红 (青岛市中心医院病理科,青岛市,266000) 时丽芳 (300162天津市,武装警察部队后勤学院附属医院病理科) ; 郑淑芳 (300162天津市,武装警察部队后勤学院附属医院病理科) ; |
| |
摘 要: |
|
关 键 词: | 趋化因子受体-4 大肠腺癌 浸润 转移 |
The expression and clinical significance of CXCR4 in colorectal adenocarcinoma |
| |
Institution: | QIN Xiao-jing,ZHAN Xiao-hong,SHI Li-fang,et al. (1Department of Pathology,the Affiliated Hospital of Logistical College of Chinese Armed Police Forces,Tianjin 300162,China 2Department of Pathology,the Central Hospital of Qingdao, Qingdao 266000, China) |
| |
Abstract: | Objective To evaluate the role and clinical significance of C-X-C chemokine receptor 4 (CXCR4) in development,infiltration and metastasis of colorectal carcinoma. Methods The expressions of CXCR4 protein were detected by SP immunohistochemical(IHC) method in 60 cases of eoloreetai adenocarci- noma, 23 cases of eolorectal adenoma and 22 cases of normal colorectal mucosa. The expressions of CXCR4 mRNA were detected by RT-PCR method in 30 cases of colorectal adenocarcinoma, 15 cases of normal col- orectal mucosa. Results IHC results showed that the expressional quantity of CXCR4 protein in the colorectal adenocarcinoma was obviously higher than that in the colorectal canalicular adenoma and normal colorectal mucosa , and the differences all had statistical significance (P all〈 0.05).The expressional quantity of CXCR4 protein in the colorectal canalicular adenoma was obviously higher than that in the normal colorectal mucosa, and the difference had statistical significance (P〈 0.01 ).The results of RT-PCR showed that the expressional quantity of CXCR4 mRNA in the colorectal adenocarcinoma was obviously higher than that in the normal col- orectal mucosa,and the difference had statistical significance (P〈 0.01 ).The positive expressions of CXCR4 protein and mRNA were closely correlated with the depth of tumor infiltration and metastasis of lymph node (P all〈 0.05), but they were not related to gender and age of patients and differentiation of cancer (P all〉 0.05). There was positive correlation between the expression of CXCR4 and CXCR4 mRNA (r= 0.588, P〈 0.01). Conclusion High expression of CXCR4 in colorectal adenocarcinoma may play an important role in tumori-genesis progression, infiltration and metastasis of colorectal adenocarcinoma. |
| |
Keywords: | C-X-C chemokine receptor 4 Colorectal adenocarcinoma Invasion Metastasis |
本文献已被 维普 等数据库收录! |
|