The role of interoceptors in the regulation of blood coagulation

Summary The role of interoceptors of carotid sinus and of the arch of aorta in acceleration of blood coagulation in acute blood loss was investigated. It was revealed by 29 experiments on rabbits and 10 on dogs that local anemia of sinocarotid zones causes reflex acceleration of blood coagulation. Blood loss in rabbits with denervated carotid sinuses is associated with the weaker response of acceleration of blood coagulation, than in normal animals. With exclusion of the sinus, depressor and vagus nerves the acceleration of the blood coagulation and increase of thrombin titer is not as considerable as following blood loss in the intact animals.Presented by Active Member Acad. Med. Sci. USSR V. V. Parin