Relation of genetic polymorphisms in microRNAs with diastolic and systolic function in type 2 diabetes mellitus |
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| Affiliation: | 1. Department of Cardiac Function, The People''s Hospital of China Medical University and the People''s Hospital of Liaoning Province, Shenyang 110016, China;2. Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;3. Department of Ultrasonography, The People''s Hospital of Zhengzhou University, Zhengzhou 450003, China;4. Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;1. Department of Urology Surgery, The Second Hospital of Jiaxing City, 1518 North Ring Road, Nanhu District, Jiaxing City, Zhejiang Province, PR China;2. Department of Urology, Huashan Hospital, Fudan University, No.12 Middle Urumqi Road, Shanghai, 200040, PR China;1. Department of Internal Medicine, “S. Maria delle Grazie” Hospital, Pozzuoli, Italy;2. Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children''s Hospital, Napoli, Italy;3. Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy;4. Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italy;5. Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Italy;6. Department of Biomedical Sciences and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Italy;7. Section of Pediatrics, Department of Translational Medical Science, Regional Center of Pediatric Diabetes, University of Naples Federico II, Napoli, Italy;8. Pediatric Department, “V. Buzzi” Children’s Hospital, Milano and Department of Internal Medicine, University of Pavia, Italy;9. Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy;10. Pediatric Department, Azienda Sanitaria Universitaria del Friuli Centrale, Hospital of Udine, Udine, Italy;11. Department of Movement Sciences and Wellbeing, University “Parthenope”, Napoli, Italy;1. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266071, China;2. Qingdao Cancer Institute, Qingdao, Shandong 266071, China;3. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong 266033, China;4. Qingdao Institute of Preventive Medicine, Qingdao, Shandong, 266033, China;5. School of Life Sciences, Tsinghua University, Beijing, 100084, China;1. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore;2. Université de Paris, CRESS, Inserm, INRAE, F-75004 Paris, France;3. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore;4. Department of Maternal Fetal Medicine, KK Women''s and Children''s Hospital, Singapore;5. Department of Paediatric Endocrinology, KK Women''s and Children''s Hospital, Singapore;6. Duke-NUS Medical School, Singapore;7. Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore;8. Liggins Institute, University of Auckland, New Zealand;9. MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK;10. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore;11. Department of Reproductive Medicine, KK Women''s and Children''s Hospital, Singapore;12. Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore;1. Ministry of Health, Manama, Bahrain;2. Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain;3. High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia;4. Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, University of Sfax, Sfax 3000, Tunisia;5. Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan;6. Somnogen Canada Inc., College Street, Toronto, Canada;7. Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India;8. The Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia, Riyadh, Saudi Arabia;9. Department of Medicine, University Sleep Disorders Center and Pulmonary Service, King Saud University, Riyadh, KSA6, Saudi Arabia;1. Department of Medical Biochemistry, University of Belgrade – Faculty of Pharmacy, Belgrade, Serbia;2. Department of Laboratory Diagnostics, University Medical Center “Be?anijska kosa”, Belgrade, Serbia;3. Department of Cardiology, University Medical Center “Be?anijska kosa” and University of Belgrade-Faculty of Medicine, Belgrade, Serbia;4. Department of Pulmonology, University Medical Center “Be?anijska kosa”, Belgrade, Serbia |
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| Abstract: | Background and aimsType 2 diabetes mellitus (T2DM) has high risk of developing cardiac dysfunction, increasing of either cardiovascular death or hospitalization for heart failure. MicroRNAs (miRNA) affect cardiac function of T2DM. The aim of this study was to investigate the relationships between five miRNA single nucleotide polymorphisms (SNP) and diastolic and systolic function of T2DM.Methods and resultsThree hundred untreated T2DM subjects were included. Each subject underwent SNP genotyping, conventional echocardiography, tissue doppler imaging, and speckle tracking imaging. The effects of miRNA SNPs on diastolic and systolic function were evaluated. The diastolic function of T2DM subjects with miR-133a-1-rs8089787 wild genotype or let-7f-rs10877887 variant genotype was lower than those with miR-133a-1-rs8089787 variant genotype or let-7f-rs10877887 wild genotype, manifesting as higher left atrial volume index, lower mean E′, and higher E/E’ (P < 0.05). There were no significant effects of miR-133a-2-rs13040413, let-7a-1-rs13293512 and miR-27a-rs895819 on the diastolic function of T2DM subjects (P > 0.05). These five miRNA SNPs had no effect on the systolic function of T2DM subjects (P > 0.05).ConclusionsMiRNA-133a-1-rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM. The findings may be a promising therapeutic targets for preventing diastolic dysfunction in T2DM. |
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| Keywords: | MicroRNA Polymorphism Type 2 diabetes mellitus Diastolic function Systolic function |
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