首页 | 本学科首页   官方微博 | 高级检索  
检索        


Use of fish oil and mortality of patients with cardiometabolic multimorbidity: A prospective study of UK biobank
Institution:1. Department of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, 410008, China;2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China;3. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China;4. Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China;1. Department of Urology Surgery, The Second Hospital of Jiaxing City, 1518 North Ring Road, Nanhu District, Jiaxing City, Zhejiang Province, PR China;2. Department of Urology, Huashan Hospital, Fudan University, No.12 Middle Urumqi Road, Shanghai, 200040, PR China;1. Department of Internal Medicine, “S. Maria delle Grazie” Hospital, Pozzuoli, Italy;2. Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children''s Hospital, Napoli, Italy;3. Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy;4. Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italy;5. Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Italy;6. Department of Biomedical Sciences and Human Oncology, Pediatric Unit, University of Bari “Aldo Moro”, Bari, Italy;7. Section of Pediatrics, Department of Translational Medical Science, Regional Center of Pediatric Diabetes, University of Naples Federico II, Napoli, Italy;8. Pediatric Department, “V. Buzzi” Children’s Hospital, Milano and Department of Internal Medicine, University of Pavia, Italy;9. Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy;10. Pediatric Department, Azienda Sanitaria Universitaria del Friuli Centrale, Hospital of Udine, Udine, Italy;11. Department of Movement Sciences and Wellbeing, University “Parthenope”, Napoli, Italy;1. Diabetes and Islet Transplantation Unit, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC (University of Pittsburgh Medical Center), Palermo, Italy;2. Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy;3. Dipartimento di Promozione Della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza “G. D''Alessandro”, PROMISE, University of Palermo, Palermo, Italy;1. Department of Cardiac Function, The People''s Hospital of China Medical University and the People''s Hospital of Liaoning Province, Shenyang 110016, China;2. Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;3. Department of Ultrasonography, The People''s Hospital of Zhengzhou University, Zhengzhou 450003, China;4. Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;1. Department of Medical Biochemistry, University of Belgrade – Faculty of Pharmacy, Belgrade, Serbia;2. Department of Laboratory Diagnostics, University Medical Center “Be?anijska kosa”, Belgrade, Serbia;3. Department of Cardiology, University Medical Center “Be?anijska kosa” and University of Belgrade-Faculty of Medicine, Belgrade, Serbia;4. Department of Pulmonology, University Medical Center “Be?anijska kosa”, Belgrade, Serbia;1. Ministry of Health, Manama, Bahrain;2. Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain;3. High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia;4. Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, University of Sfax, Sfax 3000, Tunisia;5. Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan;6. Somnogen Canada Inc., College Street, Toronto, Canada;7. Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India;8. The Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia, Riyadh, Saudi Arabia;9. Department of Medicine, University Sleep Disorders Center and Pulmonary Service, King Saud University, Riyadh, KSA6, Saudi Arabia
Abstract:Background and aimsCardiometabolic multimorbidity (CMM) has risen as a global issue of public health, with an in-creasing prevalence and more severe clinical prognosis. This study aimed to estimate the association between use of fish oil and mortality among patients with CMM.Methods and ResultsIn this prospective study based on UK Biobank, participants with ≥2 of cardiometabolic diseases (CMDs, including coronary heart disease CHD], diabetes, hypertension, and stroke in this study) at recruitment were included. Use of fish oil was derived from touchscreen questionnaires at baseline. All-cause and cardiovascular mortality were accessed via electronic health-related records. Kaplan–Meier curves and flexible parametric Royston-Parmar proportion-hazard models were fitted to assess the as-sociations of fish-oil use with all-cause, cardiovascular mortality, and related life expectancy alterations. Among 30 068 participants from UK Biobank (67.9% men; mean age 61.75 years), 5357 deaths were reported during 12.03 years of follow-up. For patients with CMM, use of fish oil was associated with a 17% lower risk of all-cause mortality (95% confidence interval 95% CI] 0.78–0.88, P < 0.001), and 19% lower risk of cardiovascular mortality (95% CI 0.72–0.90, P < 0.001) in multivariable-adjusted models. At 45 years old, using fish oil was associated with 1.66 years of life expectancy gained.ConclusionAmong patients with CMM, use of fish oil was associated with a significantly reduced risk of all-cause, cardiovascular mortality, and prolonged life expectancy.
Keywords:Fish oil  Cardiometabolic diseases  Multimorbidity  Mortality  UK Biobank  BMI"}  {"#name":"keyword"  "$":{"id":"kwrd0040"}  "$$":[{"#name":"text"  "_":"body mass index  CHD"}  {"#name":"keyword"  "$":{"id":"kwrd0050"}  "$$":[{"#name":"text"  "_":"coronary heart disease  CMDs"}  {"#name":"keyword"  "$":{"id":"kwrd0060"}  "$$":[{"#name":"text"  "_":"cardiometabolic diseases  CMM"}  {"#name":"keyword"  "$":{"id":"kwrd0070"}  "$$":[{"#name":"text"  "_":"cardiometabolic multimorbidity  ICD"}  {"#name":"keyword"  "$":{"id":"kwrd0080"}  "$$":[{"#name":"text"  "_":"International Classification of Diseases  n-3 PUFAs"}  {"#name":"keyword"  "$":{"id":"kwrd0090"}  "$$":[{"#name":"text"  "_":"omega-3 polyunsaturated fatty acids  RMST"}  {"#name":"keyword"  "$":{"id":"kwrd0100"}  "$$":[{"#name":"text"  "_":"restricted mean survival time
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号