The association between early-life famine exposure and adulthood obesity on the risk of dyslipidemia |
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| Affiliation: | 1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Consultant Haematologist and Senior Lecturer, Department of Haematology and Blood Transfusion, Faculty of Clinical Science, College of Medicine of the University of Lagos, Nigeria;4. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;5. Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Biorepository, Biomedical Research Administration, King Fahad Medical City, Riyadh, Saudi Arabia;8. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;9. College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA;1. Center for Research on Population Health, National Institute of Public Health, Mexico City, Mexico;2. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;3. National Center for Preventive Programs and Disease Control, Ministry of Health, Mexico;4. Department of Neurology and Psychiatry, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico;5. Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Nuevo Leon, Mexico;6. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;7. Channing Laboratory, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;8. Department of Medicine, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico;9. INSERM (Institut National de la Santé et de la Recherche Médicale), Center for Research in Epidemiology and Population Health (CESP), U1018, Villejuif, France;10. Paris-South University, UMRS, 1018, Villejuif, France;11. Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA;1. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;2. Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;3. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico |
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| Abstract: | Background and aimsThe joint effect of famine exposure and adulthood obesity on risk of dyslipidemia remains unclear. Thus, we aim to explore the joint effect of famine exposure and adulthood obesity on the risk of dyslipidemia, and the potential effect of adult general or abdominal obesity on the association between famine exposure and dyslipidemia.Methods and resultsWe conducted a community-based cohort study in 8880 subjects aged 40 years or older. Participants were divided into nonexposed, fetal-exposed, childhood-exposed, adolescent-exposed according to birth date. General obesity and abdominal obesity were defined according to body mass index (BMI: overweight≥24.0 kg/m2, obesity≥28.0 kg/m2) and waist-to-hip ratio (WHR, men/women: moderate≥0.90/0.85, high≥0.95/0.90). Dyslipidemia was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Compared with nonexposed participants, fetal-exposed individuals had significantly increased risk of dyslipidemia (OR:1.24, 95%CI: 1.03–1.50) in the whole study. Significant increased risk of dyslipidemia related to famine exposure was observed in women [ORs (95%CIs) were 1.36 (1.05–1.76) and 1.70 (1.22–2.37) for the fetal and childhood-exposed group, respectively] but not in men. Moreover, both general and central obesity had significant multiplicative interactions with famine exposure for the risk of dyslipidemia (P for interaction = 0.0001 and < 0.0001, respectively). Significant additive interaction was found between famine exposure and WHR on risk of dyslipidemia in women, with the relative excess risk due to interaction (RERI) and 95% CI of 0.43 (0.10–0.76).ConclusionCoexistence of early-life undernutrition and adulthood obesity was associated with a higher risk of dyslipidemia in later life. |
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| Keywords: | Famine exposure Dyslipidemia Early-life exposure Obesity BMI WHR BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" body mass index HDL-c" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" high-density lipoprotein cholesterol LDL-c" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" low-density lipoprotein cholesterol TG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" triglycerides TC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" total cholesterol WHR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" waist-to-hip ratio |
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