Effect of hyperdry amniotic membrane in preventing tendon adhesion in a rabbit model |
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| Institution: | 1. Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630, Sugitani, Toyama-City, Toyama, 930-0194, Japan;2. Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Japan;1. Department of Orthopaedic Surgery, Toyama Red Cross Hospital, 2-1-58 Ushijimahonnmachi, Toyama, 930-8562, Japan;2. Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan;3. Shijonawate Gakuen University, 5-11-10 Hokujo, Daito, 574-0011, Japan;1. Department of Orthopaedic Surgery, Tohoku University School of Medicine, Japan;2. Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University School of Medicine, Japan;1. Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Japan;2. Department of Pharmacy, Saga University Hospital, Saga, Japan;3. Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan;4. Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan;1. Tokushima Municipal Hospital, 2-34 Kita-Josanjima, Tokushima 770-0812, Japan;2. Takamatsu Municipal Hospital, 847-1 Busshozan-Ko, Takamatsu 761-8538, Japan;3. Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-5 Kuramoto, Tokushima 770-8503, Japan |
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| Abstract: | BackgroundNo anti-adhesive materials are currently in clinical use for orthopaedic surgery. We developed a hyperdry amniotic membrane (HD-AM) for easy storage and transplantation as amniotic membrane. The purpose of this study was to examine the application of HD-AM to reduce peritendinous adhesions without impairing tendon healing.MethodsWe randomly divided 3 digits (2nd, 3rd, and 4th digits) from each rabbit into three groups: a tendon repair group; a tendon repair with HD-AM group (HD-AM group); and a control group (cast only). The effects of HD-AM on peritendinous adhesions and tendon healing were examined using microscopic, histological, and mechanical analyses in a rabbit flexor digitorum profundus tendon model.ResultsAdhesions on macroscopic evaluation of the tendon repair site were significantly smaller in the HD-AM group than in the tendon repair group. Little adhesion formation or foreign body reactions were seen by on histologic evaluation in the HD-AM group. Range of motion following tendon repair was significantly better in the HD-AM group than in the tendon repair group. Maximal tensile strength required to pull the tendon from the site of adhesion was significantly smaller in the HD-AM group than in the tendon repair group. As for tendon repair site, no significant difference was seen between the tendon repair and HD-AM groups.ConclusionsHD-AM prevented peritendinous adhesion macroscopically, pathologically, and mechanically without impairing the sutured tendon. HD-AM has already been clinically applied in neurosurgery, ophthalmology, and otolaryngology, and clinical application as an anti-adhesive materials may be achieved in the future. |
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