Association between chronic hepatitis C infection and metabolic syndrome: A meta-analysis |
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| Affiliation: | 1. Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, Pakistan;2. Department of Nutritional Sciences, Rashid Latif Medical College, Lahore, Pakistan;3. Department of Food Science & Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan;4. Department of Medical Laboratory Technology, The University of Haripur, Haripur, Pakistan;5. Department of Public Health & Nutrition, The University of Haripur, Haripur, Pakistan;1. Université Frères Mentouri Constantine1 (UFMC1), institut de la nutrition, de l’alimentation et des technologies agro-alimentaires (INATAA), route d’Aïn El Bey, 25 000 Constantine, Algérie;2. Laboratoire de nutrition et technologies alimentaires (LNTA), université Frères Mentouri Constantine1 (UFMC1), route d’Aïn El Bey, 25 000 Constantine, Algérie;1. Laboratory of Biology and Health, Research Unit: Human Nutrition, URAC 34, Faculty of sciences Ben Msik, Hassan II University of Casablanca, Avenue Cdt Driss El Harti, B.P 7955, Sidi Othmane, 20660 Casablanca, Morocco;2. Faculty of medecine, Mohammed VI University of Health Sciences, UM6SS, Casablanca, Morocco;3. Faculty of Health and Social, Chester University, Parkgate Road, Chester/CH1 4BJ, Chester, United Kingdom;1. Department of Nutrition, The First Hospital of Hebei Medical University, Hebei Province Key Laboratory of Nutrition and Health, 89 Donggang Road, Shijiazhuang, Hebei 050031, China;2. College of nursing, Hebei University of Chinese Medicine, Hebei Province Key Laboratory of Nutrition and Health, 3 Xing yuan Road, Shijiazhuang 050200, Hebei Province, China;1. Reproduction Biology Center, Federal University of Juiz de Fora, Juiz de Fora, Brazil;2. Institute for Veterinary Pathology, University of Zurich, Zurich, Switzerland |
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| Abstract: | BackgroundHepatitis C virus (HCV) infected patients have been found to be more susceptible to metabolic syndrome (MetS), but the results remain unclear and lack of a meta-analysis.MethodsDatabases including PubMed, Web of Science, EMBASE and the Cochrane Library were searched to identify all studies concerning HCV and MetS. Funnel plots combined with Begg's tests and Egger's tests were used to analysis the possible publication bias. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the effect of HCV infection on the risk of MetS.ResultsEight articles, involving a total of 57387 HCV patients were included. HCV infection was significantly associated with an increased incidence of MetS (OR = 1.73; 95% CI, 1.19–2.52). After adjustment according to the sensitivity analysis, one included article was removed to decrease the publication bias and high heterogeneity, of which the results showed that HCV infection was still associated with an increased incidence of MetS (OR = 1.93; 95% CI, 1.39–2.68).ConclusionsHCV patients tend to have a significant increased risk for MetS, but more large-scale studies are needed to confirm this and explore the exact mechanism. |
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| Keywords: | HCV infection MetS Meta-analysis Infection par le VHC MetS Méta-analyse |
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