Relationship between PCSK9 and endothelial function in patients with acute myocardial infarction |
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| Affiliation: | 1. Maria Cecilia Hospital, GVM Care and Research, via Corriera 1, 48033, Cotignola RA, Italy;2. Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, via Aldo Moro 8, 44124, Ferrara, Italy;1. Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, España;2. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, España;3. Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, España;1. Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland;2. Clinical Trials Unit, Faculty of Medicine, University of Bern, Bern, Switzerland;3. Department of Cardiology and Critical Care Medicine, Hartcentrum Hasselt, Jessa Ziekenhuis, Hasselt, Belgium;4. Faculty of Medicine and Life Sciences, University of Hasselt, Hasselt, Belgium;5. University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;6. University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;7. Division of Cardiology, “Sant’Anna e San Sebastiano” Hospital, Department of Translational Medicine, University of Campania “Luigi Vanvitelli,” Caserta, Italy;8. Division of Cardiology, “Sant’Anna e San Sebastiano” Hospital, Department of Translational Medicine, University of Campania “Luigi Vanvitelli,” Caserta, Italy;9. Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy;10. Department of Cardiovascular Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;11. Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy;12. Unità Operativa Complessa di Cardiologia, Azienda Socio-Sanitaria Territoriale della Brianza (MB), Vimercate Hospital, Vimercate, Italy;13. Azienda Ospedaliera Universitaria Policlinico “Gaetano Martino,” University of Messina, Messina, Italy;14. Cardiology Department, Misericordia Hospital, Grosseto, Italy;15. IRCCS Istituto Auxologico Italiano, Ospedale San Luca, Milan, Italy;p. Cardiovascular Department, Infermi Hospital, Rimini, Italy;q. Interventional Cardiology Unit, Mediterranea Cardiocentro, Naples, Italy;r. Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla, Santander, Spain;s. Department of Biomedical Sciences, University of Italian Switzerland, Lugano, Switzerland;t. Department of Cardiology, University of Bern, Bern, Switzerland;1. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;2. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom;3. Division of Cardiovascular Diseases, University of California, San Diego, USA;1. Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece;2. School of Medicine Sydney, University of Notre Dame, Sydney, Australia;3. First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece;4. School of Psychology, University of Surrey, Guildford, UK;5. Faculty of Health, University of Canberra, Canberra, Australia;1. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Consultant Haematologist and Senior Lecturer, Department of Haematology and Blood Transfusion, Faculty of Clinical Science, College of Medicine of the University of Lagos, Nigeria;4. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;5. Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Biorepository, Biomedical Research Administration, King Fahad Medical City, Riyadh, Saudi Arabia;8. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;9. College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA;1. Center for Chronic Disease Control, Nanshan, Shenzhen, PR China;2. Department of Nutrition, School of Public Health, Sun Yat-sen University, GuangZhou, PR China;3. Department of Epidemiology, School of Public Health, Sun Yat-sen University, GuangZhou, PR China;4. Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, PR China;5. School of Public Health, Shenzhen University Health Science Center, Shenzhen, PR China |
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| Abstract: | Background and aimsWhile the role of PCSK9 in lipid metabolism is well established, its link with endothelial function is less clear. The aim of the present study is to evaluate the relationship between PCSK9 and endothelial dysfunction in the setting of acute myocardial infarction.Methods and resultsTo this purpose, we analyzed the serum of 74 patients with ST-elevation myocardial infarction (STEMI) at the time of admission and after 5 days. Endothelial dysfunction was evaluated as rate of apoptosis (AR) of human umbilical vein endothelial cells incubated with patients’ serum. There was a good correlation between PCSK9 and the apoptosis rate values, both at baseline (r = 0.649) and 5-day (r = 0.648). In the 5 days after STEMI, PCSK9 increased significantly (242–327 ng/ml, p < 0.001), while AR did not (p = 0.491). Overall, 21 (28%) patients showed a reduction of PCSK9, and they had a significantly higher decrease of AR as compared to others (?13.87 vs 5.8%, p = 0.002). At the univariable analysis, the 5-day change of PCSK9 resulted to be the only variable associated with the 5-day change of the apoptosis rate (beta 0.217, 95%CI 0.091–0.344, p = 0.001).ConclusionThe variation of endothelial function and PCKS9 in the first days after an acute myocardial infarction are related. Further validation and research are necessary to confirm our findings.Clinical trialNCT02438085. |
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| Keywords: | Endothelial function PCSK9 Myocardial infarction |
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