| 槲皮素改善骨质疏松的作用机制研究进展 |
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| 引用本文： | 王龙飞,高玉海,谢高倩,陈克明.槲皮素改善骨质疏松的作用机制研究进展[J].现代药物与临床,2023,38(3):714-718. |
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| 作者姓名： | 王龙飞 高玉海 谢高倩 陈克明 |
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| 作者单位： | 中国人民解放军联勤保障部队第九四〇医院基础医学实验室, 甘肃 兰州 730050;甘肃农业大学生命科学技术学院, 甘肃 兰州 730070;甘肃省干细胞与基因药物重点实验室, 甘肃兰州 730050;中国人民解放军联勤保障部队第九四〇医院基础医学实验室, 甘肃 兰州 730050;甘肃省干细胞与基因药物重点实验室, 甘肃兰州 730050 |
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| 基金项目： | 国家自然科学基金面上项目（81770879）；甘肃省青年科技基金计划项目（20JR5RA589）；联勤保障部队第九四〇医院实验室培育项目（2021yxky081）；联勤保障部队第九四〇医院青年培育项目（2021yxky053） |
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| 摘 要： | 骨质疏松症是目前老龄化社会急需解决的慢性骨科疾病，是一种以骨量丧失、骨微结构恶化为特征的全身性骨骼疾病，因此如何有效地预防和治疗骨质疏松症越来越受到人们的关注。槲皮素是自然界广泛存在天然黄酮醇类化合物，具有雌激素样作用，可抑制骨吸收和促进骨形成。槲皮素通过抑制破骨细胞、调控骨髓间充质干细胞的细胞机制，促进骨形成、抑制骨吸收的信号通路机制，以及雌激素信号途径改善骨质疏松。综述了槲皮素改善骨质疏松的作用机制，希望为槲皮素的临床应用提供参考。
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| 关 键 词： | 槲皮素 骨质疏松症 破骨细胞 骨髓间充质干细胞 雌激素 信号通路 |
| 收稿时间： | 2022/10/11 0:00:00 |
Research progress on mechanism of quercetin in improving osteoporosis |
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| WANG Long-fei,GAO Yu-hai,XIE Gao-qian,CHEN Ke-ming.Research progress on mechanism of quercetin in improving osteoporosis[J].Drugs & Clinic,2023,38(3):714-718. |
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| Authors: | WANG Long-fei GAO Yu-hai XIE Gao-qian CHEN Ke-ming |
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| Institution: | Basic Medical Laboratory, No. 940 Hospital of Joint Logistics Support force of Chinese PLA, Lanzhou 730050, China;College of Life Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;Gansu Key Laboratory of Stem Cells and Genetic Drug, Lanzhou 730050, China;Basic Medical Laboratory, No. 940 Hospital of Joint Logistics Support force of Chinese PLA, Lanzhou 730050, China;Gansu Key Laboratory of Stem Cells and Genetic Drug, Lanzhou 730050, China |
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| Abstract: | Osteoporosis is a chronic orthopedic disease urgently needed to be solved in the aging society, and it is a systemic bone disease characterized by bone loss and deterioration of bone microstructure, so how to effectively prevent and treat osteoporosis has attracted more and more attention. Quercetin is a natural flavonol compound widely existing in nature, and it has the effect of estrogen, and can inhibit bone resorption and promote bone formation. Quercetin can improve osteoporosis by inhibiting osteoclasts, regulating bone marrow mesenchymal stem cells, promoting bone formation, inhibiting bone resorption, and regulating estrogen signal pathway. This article reviews the mechanism of quercetin in improving osteoporosis, hoping to provide a reference for the clinical application of quercetin. |
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| Keywords: | quercetin osteoporosis osteoclast bone marrow mesenchymal stem cell estrogen signal pathway |
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