Association of dietary factors with plasma homocysteine and coronary heart disease outcome |
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| Institution: | 1. Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, Pakistan;2. Department of Nutritional Sciences, Rashid Latif Medical College, Lahore, Pakistan;3. Department of Food Science & Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan;4. Department of Medical Laboratory Technology, The University of Haripur, Haripur, Pakistan;5. Department of Public Health & Nutrition, The University of Haripur, Haripur, Pakistan;1. Department of Metabolism and Endocrinology, The Affiliated Zhuzhou Hospital, Xiangya Medical College CSU, Zhuzhou, China;2. Department of Hepatobiliry and Pancreatic Surgery, The Affiliated Zhuzhou Hospital, Xiangya Medical College CSU, China;1. Laboratory of Biology and Health, Research Unit: Human Nutrition, URAC 34, Faculty of sciences Ben Msik, Hassan II University of Casablanca, Avenue Cdt Driss El Harti, B.P 7955, Sidi Othmane, 20660 Casablanca, Morocco;2. Faculty of medecine, Mohammed VI University of Health Sciences, UM6SS, Casablanca, Morocco;3. Faculty of Health and Social, Chester University, Parkgate Road, Chester/CH1 4BJ, Chester, United Kingdom;1. Department of Nutrition, The First Hospital of Hebei Medical University, Hebei Province Key Laboratory of Nutrition and Health, 89 Donggang Road, Shijiazhuang, Hebei 050031, China;2. College of nursing, Hebei University of Chinese Medicine, Hebei Province Key Laboratory of Nutrition and Health, 3 Xing yuan Road, Shijiazhuang 050200, Hebei Province, China |
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| Abstract: | ObjectiveThe aim of the present study was to investigate the association between serum levels of vitamins B12, B6, folic acid and hyperhomocysteinemia with the risk of coronary heart disease (CHD).Material and methodsA case control study was carried out involving 105 newly diagnosed coronary heart disease patient of both gender (age range 25–60 years) and 105 age and sex matched normal healthy individuals at Punjab Institute of Cardiology, Lahore. Fasting blood samples were collected from both cases and controls. Sera were analyzed for folic acid, vitamin B6 and B12 using high performance liquid chromatography (HPLC). Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) and traditional risk factors were also assessed.ResultsMean plasma homocysteine level in cases (22.33 ± 9.22 μmol/L) was significantly higher (P = 0.0001) than controls (12.5 ± 3.73 μmol/L). Mean serum folic acid concentration, serum vitamin B6 and vitamin B12 were significantly lower in cases than the mean levels in controls (P < 0.05). When compared to controls the data revealed significantly greater deficiency of folic acid, vitamin B6 and B12 in coronary heart disease patients. Statistically significant inverse correlation was observed between folic acid, vitamin B6, B12 and plasma homocysteine concentration (r = ?0.463, r = ?0.431 and r = ?0.294, respectively).ConclusionNutritional deficiency of folic acid, vitamin B12 and B6 were common in coronary heart disease patients with an inverse correlation of plasma homocysteine concentration with these vitamins. Substantial deficiency of these vitamins along with hyperhomocysteinemia could be further aggravating the risk of CHD in Pakistani population. |
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| Keywords: | Coronary heart diseases Homocysteine Dietary factors Vitamin B6 Vitamin B12 Folic acid Maladies coronariennes Homocystéine Facteurs alimentaires Vitamine B6 Vitamine B12 Acide folique |
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