Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up |
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| Institution: | 1. IRCCS AOU S. Orsola-Malpighi, Bologna, Italy;2. Hypertension and Cardiovascular Risk Factors Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy;1. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Consultant Haematologist and Senior Lecturer, Department of Haematology and Blood Transfusion, Faculty of Clinical Science, College of Medicine of the University of Lagos, Nigeria;4. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;5. Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Biorepository, Biomedical Research Administration, King Fahad Medical City, Riyadh, Saudi Arabia;8. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;9. College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA;1. Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece;2. School of Medicine Sydney, University of Notre Dame, Sydney, Australia;3. First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece;4. School of Psychology, University of Surrey, Guildford, UK;5. Faculty of Health, University of Canberra, Canberra, Australia;1. Institute of Medical Epidemiology, Biometrics and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany;2. Department of Internal Medicine III - Cardiology, Mid-German Heart Center, University Hospital Halle (Saale), Halle, Germany;3. Department of Cardiac Surgery, Mid-German Heart Center, University Hospital Halle (Saale), Halle, Germany;4. Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany |
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| Abstract: | Background and aimsTo evaluate the long-term effect of simultaneous treatment of hypertension and hypercholesterolemia with angiotensin-converting enzyme (ACE) inhibitors and statins on the incidence of major cardiovascular events (MACE) and other clinical outcomes.Methods and resultsWe considered data from a subset of Brisighella Heart Study (BHS) participants who were consecutively evaluated in three epidemiological surveys between 2012 and 2020. We excluded normotensive subjects and individuals with a low calculated 10-year CVD risk, hypertensive patients treated with antihypertensive drugs different from ACE inhibitors and patients who changed antihypertensive medications during follow-up. The remaining participants were divided into four groups depending on whether they were treated with (I) perindopril ± amlodipine without statin treatment (N. 132), (II) perindopril ± amlodipine and atorvastatin (N. 132), (III) an ACE inhibitor other than perindopril ± a calcium-channel blocker without statin therapy (N. 133), (IV) an ACE inhibitor other than perindopril ± a calcium-channel blocker and statin therapy (N. 145). The long-term (8 years) effects of the different combined treatment were compared among the pre-defined groups. Over the follow-up period of 8 years, the proportion of subjects who developed MACE, type 2 diabetes mellitus and hyperuricemia, and the proportion of subjects needing for the intensification of antihypertensive treatment to improve blood pressure control were statistically different among the predefined groups (P < 0.05).ConclusionCombined treatment with ACE inhibitors and statins (especially atorvastatin) in hypertensive patients seems to significantly reduce the risk of developing CVD in comparison with treatment with ACE inhibitors alone. |
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| Keywords: | Hypertension ACE inhibitors Perindopril Amlodipine Hyper-cholesterolemia Statins Atorvastatin |
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