| DNA损伤修复调控因子与肿瘤耐药的研究进展 |
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| 引用本文： | 赵欣楠,魏敏杰,赵琳. DNA损伤修复调控因子与肿瘤耐药的研究进展[J]. 陕西肿瘤医学, 2013, 0(11): 2608-2612 |
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| 作者姓名： | 赵欣楠 魏敏杰 赵琳 |
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| 作者单位： | [1]中国医科大学七年制临床医学专业,辽宁沈阳110001 [2]中国医科大学药学院药理教研室,辽宁沈阳110001 |
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| 基金项目： | 国家自然科学基金资助项目（编号81173092,81202551）;辽宁省科技厅科学技术计划资助项目（编号2011415052,20111107） |
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| 摘 要： | DNA分子是生物细胞中易受辐射损伤的敏感分子,亦称靶分子.多种理化因素如紫外线、电离辐射、化学诱变剂等导致细胞DNA损伤,同时生物体内本身又存在修复体系.肿瘤细胞DNA修复能力与化疗药物敏感性密切相关.本文综述DNA损伤修复机制-碱基切除修复、核苷酸切除修复、错配修复、DNA双链断裂修复等研究进展以及与肿瘤耐药之间的联系.
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| 关 键 词： | DNA损伤修复 肿瘤细胞 耐药性 |
Advance on DNA damage repair and tumor drug resistance |
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| Zhao XinnanChina Medical University,Liaoning Shenyang,China Wei Minjie. Advance on DNA damage repair and tumor drug resistance[J]. Shaanxi Oncology Medicine, 2013, 0(11): 2608-2612 |
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| Authors: | Zhao XinnanChina Medical University Liaoning Shenyang China Wei Minjie |
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| Affiliation: | Zhao Xinnan(China Medical University, Liaoning Shenyang 110001, China) Wei Minjie(Department of Pharmacology, College of Pharmacy, China Medical University, Liaoning Shenyang 110001, China) Zhao Lin(Department of Pharmacology, College of Pharmacy, China Medical University, Liaoning Shenyang 110001, China) |
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| Abstract: | DNA molecules are sensitive or target ones which are liable to be damaged by radiation.A variety of physical or chemical factors,such as ultraviolet light,ionizing radiation and chemical mutagen can damage DNA molecules in cells.However,repair system exists in organism.The repair ability of DNA molecules is closely related to the chemotherapy drug sensitivity in tumor cells.In this article,we review the latest progress on mechanisms of DNA damage repair-base excision repair,nucleotide excision repair,mismatch repair,double strand breaks repair as well as the relationship between them and tumor resistance. |
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| Keywords: | DNA damage repair tumor cell resistance |
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