不同孕期及分娩后妇女血清骨钙素浓度的变化

对１４２例不同孕期妇女、３０例分娩后妇女、４７例相应年龄非妊娠健康妇女，分别测量血清骨钙素（ＢＧＰ）、碱性磷酸酶（ＡＫＰ）和钙（Ｃａ）、磷（Ｐ）。结果：血清ＢＧＰ水平，妊娠早期、妊娠中期、妊娠晚期与非妊娠组比较，Ｐ值分别为Ｐ＞０．０５，Ｐ＜０．０１，Ｐ＜０．００１。分娩后即刻测定的血清ＢＧＰ水平，明显高于妊娠各期（Ｐ＜０．００１），呈一个明显的高峰。分娩后第五天降至正常。血清ＡＫＰ水平随妊娠的周数增加而升高，妊娠晚期与非妊娠组比较，差异有极显著性（Ｐ＜０．０１）。本研究结果说明，不同孕期、分娩后妇女骨的代谢有较明显的改变，血清ＢＧＰ、ＡＫＰ是骨代谢瞬间变化的生化指标，为探讨不同孕期及分娩后骨代谢变化提供了依据。

Changes of Osteocalcin levels in pregnant andpost partum women

he concentration of plasma osteocalcin, or boneGLA protein (BGP), alkaline phosphatase (AKP),calcium and phosphate were measured in 142 pregnantwomen at various stages of pregnancy andpostpartum, and also in another 47 healthy non-preg-nant women as control. In contrast to the controlgroup, plasma BGP level showed significant increaseat second and third trimester (P< 0.01 and P< 0.001respectively), with the peak level at immediatepostpartum period and returned to normal in 5 days.Serum AKP level increased as pregnancy progress.and there was significant difference between the levelsat the 3rd trimester and that at non-pregnant status(P<0.01). This study demonstrated that there wasmarked bone metabolism changes during pregnancy,and it indicated that osteocalcin might play a role inthe regulation of bone metabolism.