急性病毒性心肌炎C反应蛋白的变化及与心肌损伤指标相关性研究

目的:探讨急性病毒性心肌炎患者血C反应蛋白(CRP)水平的变化及其与心肌损伤指标间的关系。方法:49例急性病毒性心肌炎患者分为轻症(30例)和重症(19例)两组。入院第1、3、7、14天分别测定CRP,并同步测定肌酸磷酸激酶MB(CK-MB)和肌钙蛋白T(TnT)浓度。结果:CRP高峰出现在急性病毒性心肌炎早期,重症病毒性心肌炎组的CRP水平显著高于轻症组(P<0.01),且持续时间长,第14天才恢复正常。重症组CRP水平与CK-MB及TnT呈正相关(P<0.01)。结论:急性病毒性心肌炎患者CRP水平可反映其病情的严重程度,并与心肌损伤的严重程度相关。

A study of C reactive protein concentration and its correlation with myocardial injury markers in acute viral myocarditis

Objective To investigate the C reactive protein (CRP) concentration and its correlation with myocardial injury markers in acute viral myocarditis. Methods Forty-nine patients with acute viral myocarditis were divided into the slight group (n=30) and the severe group (n=19). The concentrations of CRP, CK-MB and TnT were simultaneously measured. Results The concentrations of CRP in the severe group were higher than those in the slight group (P<0.01). The CRP was related with CK-MB and TnT (r=0.69, P<0.01). Conclusions The concentrations of CRP may indicate the severity of acute viral myocarditis and are related with the severity of myocardial injury.