| 肝内型门脉高压症形成中大鼠门静脉零应力状态的变化 |
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| 引用本文： | 施斌,朱樑,谢渭芬,张忠兵,吴国强.肝内型门脉高压症形成中大鼠门静脉零应力状态的变化[J].生物医学工程学杂志,2006,23(4):753-755. |
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| 作者姓名： | 施斌 朱樑 谢渭芬 张忠兵 吴国强 |
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| 作者单位： | 1. 第二军医大学,长征医院,消化内科,上海,200003
2. 复旦大学,力学与工程科学系,上海,200433 |
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| 摘 要： | 用CCl4注射法制备大鼠肝内型门脉高压模型，通过观察门静脉张开角的大小，研究肝内型门脉高压大鼠在模型建立过程中不同时间点门静脉零应力状态的变化。结果发现，在门脉高压症形成中．大鼠门静脉张开角逐渐增大，从CCl4注射第10周起与对照组相比有显著性差异（P〈0．05）。表明在门脉高压形成过程中，门静脉存在非均匀性生长，门脉高压大鼠门静脉的残余应力和应变大于正常大鼠。
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| 关 键 词： | 门脉高压症 零应力状态 血管重建 门脉高压大鼠 |
| 收稿时间： | 2004-03-24 |
| 修稿时间： | 2004-03-242004-07-07 |
Change of Zero-stress State of Portal Vein in the Rat during the Pathogenesis of Intrahepatic Portal Hypertension |
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| Shi Bin,Zhu Liang,Xie Weifen,Zhang Zhongbing,Wu Guoqiang.Change of Zero-stress State of Portal Vein in the Rat during the Pathogenesis of Intrahepatic Portal Hypertension[J].Journal of Biomedical Engineering,2006,23(4):753-755. |
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| Authors: | Shi Bin Zhu Liang Xie Weifen Zhang Zhongbing Wu Guoqiang |
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| Institution: | Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. |
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| Abstract: | A model of intrahepatic portal hypertension was established in SD rats by injection of carbon tetrachloride(CCl_4).By observing the opening angle of the portal vein,the zero-stress state of the portal veins was studied at different time during the pathogenesis of intrahepatic portal hypertension.After CCl_4 injection,the opening angles of the portal veins were increased, in the tenth week,they were much greater than those in the corresponding controls(P<0.05).The results suggest that during the pathogenesis of portal hypertension,unequal remodeling exists in the portal veins to change its biomechanical properties,and the residual stress and strain of the portal veins in portal hypertensive rats are greater than those in normal controls. |
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| Keywords: | Portal hypertension(PHT) Zero-stress state Vascular remodeling Portal hypertensive rats |
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