Tissue plasminogen activator,plasminogen activator inhibitor-1 and von willebrand factor in rheumatoid arthritis |
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Authors: | Dr. S. Wållberg-Jonsson G. H. Dahlén T. K. Nilsson M. Rånby S. Rantapää-Dahlqvist |
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Affiliation: | (1) Department of Clinical Chemistry, University Hospital, Umeå;(2) Institution of Medical Biochemistry, University of Umeå, Sweden;(3) Department of Rheumatology, University Hospital, S-901 85 Umeå, Sweden |
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Abstract: | Summary Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembolic events (TE) registered in a 2-year follow-up period. Patients with extra-articular disease had a significant increase in PAI-1 activity and reduced tPA release in the venous occlusion test. von Willebrand factor, PAI-1 and also haptoglobin and triglycerides were significantly increased in the group of patients who later suffered from TE. In a multiple regression model, in which cholesterol, triglycerides and lipoprotein (a) showed significant association with TE, vWF had the strongest additive explanatory value. No distinct acute phase pattern of PAI-1 was found in any patient subgroup. |
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Keywords: | Tissue Plasminogen Activator Plasminogen Activator Inhibitor-1 von Willebrand Factor Fibrinolysis Rheumatoid Arthritis |
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