蒙药那如-3及其与旋磁场联用对大鼠脑组织自由基代谢的影响

目的:观察蒙药那如-3及其与旋磁场联用对大鼠脑组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)和一氧化氮(NO)含量的影响.方法:用邻苯三酚法测SOD,TBA法测MDA,改良的Griess法测NO.结果:与对照组相比,蒙药单用及蒙药与旋磁场联用SOD活力均显著提高,且联用组明显高于对照组;MDA含量均显著减少,其联用组明显低于对照组;联用组可显著提高NO含量.单用与联用组比较,联用组可显著提高SOD活力,可显著降低MDA含量,但NO含量提高不显著,差异无统计学意义.结论:蒙药那如-3及其与旋磁场联用均可影响大鼠脑组织自由基代谢.

Effect of Mongolian Herbal Medicine Naru-3 and Rotating Magnetic Field in Combination on Free Radical Metabolism in the Brain Tissues of Rat

Objective: To observe the effect of Mongolian herbal medicine Naru-3 combined with rotating magnetic field on the contents of superoxide dismutase (SOD), malon-dialdehyde (MDA) and nitric oxide (NO) in the brain tissues of rat.Methods:SOD activity was determined with trihydroxy benzene;MDA content,with TBA;and NO content,with improved Griess method.Results:Mongolian herbal medicine Naru-3,either used alone or used in combination with rotating magnetic field,can increase SOD activity in the brain tissues of rat but,when it is used with rotating magnetic field,the SOD activity is remarkably higher than that in the control group,MDA content is significantly decreased and it is much lower in the combined group than that in the control group.When used in combination,it can riase the NO content to a much higher level,compared with the used-alone group,Naru-3 used in combination with rotating magnetic field can increase SOD activity notably and can decrease MDA content.But the rise of NO content is unnoticeable,with no statistical significance.Conclusion:Mongolian herbal medicine Naru-3,either used alone or in combination with rotating magnetic field can influence the metabolism of free radicals in the brain tieeues of rat.