| 特发性无精症患者Y染色体AZF基因微缺失检测 |
| |
| 引用本文： | 宋国英,陈辉,李晓雯,刘华,连建华. 特发性无精症患者Y染色体AZF基因微缺失检测[J]. 郑州大学学报(医学版), 2005, 40(6): 1147-1149 |
| |
| 作者姓名： | 宋国英 陈辉 李晓雯 刘华 连建华 |
| |
| 作者单位： | 郑州大学基础医学院细胞生物与医学遗传学教研室,郑州,450052 |
| |
| 摘 要： | 目的：特发性无精及严重少精患者Y染色体末端AZF基因微缺失情况.方法：应用PCR技术对107例无精及严重少精患者及20例有生育能力的正常男性进行Y染色体SRY、AZFa、AZFb、AZFc的微缺失检测.结果：11例无精症患者存在AZFc基因的微缺失,未检测出AZFa、AZFb及SRY基因的缺失,20例有生育能力的正常男性均无SRY、AZFa、AZFb、AZFc的微缺失.结论：AZFc是引起无精和造成男性不育的原因之一.
|
| 关 键 词： | Y染色体 男性不育 AZF基因 |
| 收稿时间： | 2004-11-30 |
| 修稿时间： | 2004-11-30 |
Detection of AZF gene microdeletion in Y chromosome for patients with idiopathic azoospermia and severe oligozoospermia |
| |
| SONG Guoying,CHEN Hui,LI Xiaowen,LIU Hua,LIAN Jianhua. Detection of AZF gene microdeletion in Y chromosome for patients with idiopathic azoospermia and severe oligozoospermia[J]. Journal of Zhengzhou University: Med Sci, 2005, 40(6): 1147-1149 |
| |
| Authors: | SONG Guoying CHEN Hui LI Xiaowen LIU Hua LIAN Jianhua |
| |
| Affiliation: | Department of Cellular Biology and Medical Genetics, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052 |
| |
| Abstract: | Aim: To study the microdeletion of AZF gene in Y chromosome for the patients with idiopathic azoospermia and severe oligozoospermia. Methods: Microdeletion detection at the AZFa,AZFb,AZFc,SRY region of Y chromosome in 82 cases of azoospermia, 25 cases of severe oligozoospermia and 20 normal male controls was performed using the PCR technique. Results: Eleven patients with azoospermia had the AZFc microdeletion, and no deletion of AZFa, AZFb,AZFc or SRY region of Y chromosome in normal control was found. Conclusion: Microdeletion of AZFc in Y chromosome is a major cause of azoospermia leading to male infertility. It is necessary to detect the microdeletion of Y chromosome at genetic counsultation. |
| |
| Keywords: | Y chromosome male infertility AZF gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
