通心络对糖尿病患者血管内皮损伤的影响

目的研究通心络胶囊对糖尿病患者血管内皮细胞功能的影响。方法随机将60例糖尿病（DM）患者分为常规治疗组（30例）和通心络治疗组（30例）,后者在糖尿病常规降糖治疗的基础上加用通心络治疗,治疗8周,观察两组用药前后vonWille-brand因子（vWF）、超氧化物歧化酶（SOD）、血糖、血脂等指标的变化。结果治疗后,通心络治疗组vWF明显低于常规治疗组（P〈0.01）,SOD明显高于常规治疗组（P〈0.01）,血脂明显低于常规治疗组（P〈0.01）。结论通心络能够减轻DM患者的血管内皮细胞的损伤,可以预防和延缓糖尿病并发症的发生和发展。

Effect of Tongxinluo Capsule on Vascular Endothelial Injury in Patients with Diabetes Mellitus

Objective To study the effect of Tongxinluo capsule on vascular endothelial injure in patients with diabetes mellitus.Methods 60 patients with diabetes mellitus were randomly divided into common group and Tongxinluo group.The former was treated with insulin or oral hypoglycemic agents,the latter was added with Tongxinluo capsule oral based on aforesaid therapy.Plasma von Willebrand Factor(vWF)and superoxide dismutase(SOD)were measured before and after treatment.Results After treated with Tongxinluo,The plasma level of vWF was lower than that of common(P<0.01),as well as the level of lipid(P<0.01),while the plasma level of SOD was higher(P<0.01).Conclusion Tongxinluo can protect the of vascular endothelial cells from diabetes mellitus,that may play a role in prevention of the complication.