Hepatitis B virus propagated in a rat hepatoma cell line is infectious in a primate model |
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| Authors: | C Shih M Y Yu L S Li J W Shih |
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| Institution: | Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19104-6059. |
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| Abstract: | The human hepatitis B virus (HBV) produced by a rat hepatoma cell line through transfection with HBV DNA is infectious in the human primate model--chimpanzee. Since hepadnaviruses are known to have an extremely narrow host range, our results support the idea that the host species barrier of HBV infection resides on the penetration/adsorption step rather than any postpenetration intracellular event during the virus life cycle. |
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