| 寒痹康汤对实验性关节炎大鼠血清IL-6 NO的影响 |
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| 引用本文： | 庞学丰,高立珍,吴燕红,唐丽萍,李爱媛,梁景云,张红,任志宏,刘欢.寒痹康汤对实验性关节炎大鼠血清IL-6 NO的影响[J].辽宁中医杂志,2009(3):481-482. |
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| 作者姓名： | 庞学丰 高立珍 吴燕红 唐丽萍 李爱媛 梁景云 张红 任志宏 刘欢 |
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| 作者单位： | 广西中医学院附属瑞康医院; |
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| 基金项目： | 广西科学基金项目(桂科青0640057);;广西教育厅科研项目(200710LX016) |
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| 摘 要： | 目的:观察寒痹康汤对实验性关节炎大鼠的血清白介素-6(IL-6)、一氧化氮(NO)的影响,探讨寒痹康汤治疗类风湿关节炎的作用机理。方法:采用牛II型胶原蛋白诱导实验性关节炎模型,以甲氨蝶呤作对照,观察大鼠的关节肿胀指数的变化,采用放射免疫法检测各组大鼠血清IL-6、NO水平。结果:寒痹康汤能显著减轻大鼠关节肿胀指数、显著降低大鼠血清IL-6、NO水平。结论:寒痹康汤能下调实验性关节炎大鼠血清IL-6、NO的水平,其作用与甲氨蝶呤相当,是其治疗类风湿关节炎的作用机理之一。
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| 关 键 词： | 寒痹康汤 实验性关节炎 IL-6 NO |
Han Bi Kang Tang on experimental arthritis in rats serum IL-6,NO impact |
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| PANG Xue-feng,GAO Li-zhen,WU Yan-hong,TANG Li-ping,LI Ai-yuan,LIANG Jing-yun,ZHANG Hong,REN Zhi-hong,LIU Huan.Han Bi Kang Tang on experimental arthritis in rats serum IL-6,NO impact[J].Liaoning Journal of Traditional Chinese Medicine,2009(3):481-482. |
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| Authors: | PANG Xue-feng GAO Li-zhen WU Yan-hong TANG Li-ping LI Ai-yuan LIANG Jing-yun ZHANG Hong REN Zhi-hong LIU Huan |
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| Institution: | Rui Kang Affiliated Hospital of Guang Xi TCM Institute 10# Huadong Road;Nanning;Guangxi 530011 |
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| Abstract: | Objective:To observe the impact of the Han Bi Kang Tang on experimental arthritis in rats serum IL-6(IL-6),nitric oxide(NO),and discuss Mechanism of the Han Bi Kang Tang treatment of rheumatoid arthritis.Methods:bovine type II collagen-induced arthritis in experimental models to methotrexate for the control and observation of swelling in the joints of the index changes,the use of radioimmunoassay were detected level in serum IL-6,NO.Results:Han Bi Kang Tang can be significantly reduced joint swelling in rat... |
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| Keywords: | Han Bi Kang Tang experimental arthritis IL-6 NO |
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