| 头穴丛刺结合环境刺激对缺氧缺血性脑损伤新生大鼠海马MAP-2和p38表达影响的实验研究 |
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| 引用本文： | 刘波,唐强,邢艳丽,白震民,颜培宇,关莹,孔妍.头穴丛刺结合环境刺激对缺氧缺血性脑损伤新生大鼠海马MAP-2和p38表达影响的实验研究[J].针灸临床杂志,2011,27(2):63-65. |
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| 作者姓名： | 刘波 唐强 邢艳丽 白震民 颜培宇 关莹 孔妍 |
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| 作者单位： | 黑龙江中医药大学附属第二医院,黑龙江,哈尔滨,150001 |
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| 基金项目： | 哈尔滨市科技创新人才研究专项资金项目 |
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| 摘 要： | 目的:探讨头穴丛刺结合环境刺激对缺氧缺血性脑损伤新生大鼠海马微管相关蛋白-2和突触素表达的影响。方法:7日龄Wistor大鼠通过结扎左侧颈总动脉后,吸入8%的氮氧混合气体2 h,制成缺氧缺血性脑病(HIE)模型。随机分为5组,假手术组(A)16只,造模组(B)16只,头穴丛刺组(C)16只,环境刺激组(D)16只,头穴丛刺加环境刺激组(E)16只。治疗14天和28天后采用免疫组织化学方法对海马微管相关蛋白-2和突触素的表达进行分析。结果:海马微管相关蛋白-2和突触素的免疫组化结果显示,C、D、E组MAP-2和P38的表达在14天和28天时均高于A、B组(P<0.01),而E组与C、D组比较有显著性差异(P<0.01)。结论:头穴丛刺结合环境刺激可促进HIBD后大鼠海马微管相关蛋白-2和突触素的阳性表达。
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| 关 键 词： | 缺氧缺血性脑损伤 头穴丛刺 环境刺激 |
An Experimental Study on the Effects of Cluster Needling of Scalp Point Therapy Combined with Environmental Stimulation on Microtubuleassociated Protein-2 and Synaptophysin of Neonatal Rats with Hypoxic-ischemic Brain Injury |
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| LIU Bo,TANG Qiang,XING Yan-li,BAI Zhen-min,YAN Pei-yu,GUAN Ying,KONG Yan.An Experimental Study on the Effects of Cluster Needling of Scalp Point Therapy Combined with Environmental Stimulation on Microtubuleassociated Protein-2 and Synaptophysin of Neonatal Rats with Hypoxic-ischemic Brain Injury[J].Journal of Clinical Acupuncture and Moxibustion,2011,27(2):63-65. |
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| Authors: | LIU Bo TANG Qiang XING Yan-li BAI Zhen-min YAN Pei-yu GUAN Ying KONG Yan |
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| Institution: | LIU Bo,TANG Qiang,XING Yan-li,BAI Zhen-min,YAN Pei-yu,GUAN Ying,KONG Yan(The Second Affiliated Hospital of Heilongjiang Universiity of Chinese Medicine,Harbin 150001,China) |
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| Abstract: | Objective:To discuss the effects of cluster needling of scalp point therapy combined with environmental stimulation on microtubule-associated protein-2 and synaptophysin of neonatal rats with hypoxic-ischemic brain damage.Methods:7 days Wistor rats by ligation of the left common carotid artery were exposed to 8% of the nitrogen-oxygen mixture for two hours to make hypoxic ischemic encephalopathy(HIE) model.They are randomly divided into 5 groups:16 rats in sham operation group(A),16 rats in operation group(... |
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| Keywords: | Hypoxic-ischemic brain injury Cluster needling of scalp point Environmental stimuli |
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