Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial |
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Authors: | HC Diener,A Gendolla,A Feuersenger,S Evers,A Straube,H Schumacher,& G Davidai |
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Affiliation: | Department of Neurology and Headache Centre, University Hospital Essen,;Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen,;Department of Neurology, University of Münster, Münster,;Department of Neurology, Ludwig Maximilians University, Munich,;Boehringer Ingelheim Pharma GmbH &Co. KG, Ingelheim, Germany, and;Boehringer Ingelheim, Greenwich, CT, USA |
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Abstract: | We evaluated telmisartan 80 mg for migraine prophylaxis. Migraine patients ( n = 95) with three to seven migraine attacks in 3 months were randomized, double-blind to telmisartan or placebo. The primary end-point was the reduction in the number of migraine days (i.e. a day with ≥ 1 h of symptoms) between the 4-week baseline period and the last 4 weeks of the 12-week treatment period. A responder was recorded when there was a symptom reduction of ≥ 50% in these 4-week baseline and treatment periods. The reduction in migraine days was 1.65 with telmisartan and 1.14 with placebo ( P > 0.05). Post hoc analyses adjusting for baseline and centre showed a 38% reduction in migraine days with telmisartan vs. 15% with placebo ( P = 0.03), and a borderline significant difference in responders (40% vs. 25%, P = 0.07). The incidence of adverse events was similar between treatments. This study indicates that telmisartan might be effective in migraine prophylaxis. |
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Keywords: | Migraine migraine prophylaxis telmisartan placebo-controlled trial |
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