High-density lipoprotein cholesterol and angiographic coronary artery disease in black patients |
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| Affiliation: | 1. Division of Nutrition Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Science, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland;2. Laboratory of Molecular Biology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland;3. Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland;4. Department of Radiobiology and Immunology, Institute of Biology, Jan Kochanowski University, Świetokrzyska 15, 25-406 Kielce, Poland;5. Airworthiness Division, Air Force Institute of Technology, Ks. Boleslawa 6, 01-494 Warsaw, Poland;6. Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Sucharskiego 2, 35-225 Rzeszów, Poland;7. Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland;1. Postgraduate Program on Translational Biomedicine, Grande Rio University, Rua Professor José de Souza Herdy, 1216 - Jardim Vinte e Cinco de Agosto, Duque de Caxias, Rio de Janeiro, Brazil;2. Brazilian Branch of the Institute of Biotribocorrosion and Nanomedicine (IBTN-Br), Brazil;3. Laboratory of Bioengineering and In Vitro Toxicology, Directory of Metrology Applied to Life Sciences (Dimav), National Institute of Metrology Quality and Technology (INMETRO), Duque de Caxias, RJ, Brazil;4. European Centre for the Sustainable Impact of Nanotechnology, ECSIN LAB, Piazza Salvemini, 13 I-35131, Padova, Italy;5. National Research Centre for the Working Environment, Lerso Parkallé 105, DK-2100 Copenhagen, Denmark;6. Physics Department, São Paulo State University – UNESP, Av. Eng. Luiz Edmundo Carrijo Coube, Bauru, São Paulo, Brazil;7. Helmholtz-Centre for Environmental Research –UFZ, Permoserstraße 15, 04318 Leipzig, Germany;8. University Ca'' Foscari Venice, Dorsoduro, 3246, 30123 Venezia, Italy;9. Fluminense Federal University, Dental School, R. Miguel de Frias, 9 - Icaraí, Niterói, Brazil |
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| Abstract: | The clinical epidemiology of coronary artery disease (CAD) among black patients has not been well described, particularly in relation to the impact of the major risk factors. Lipoprotein profiles and other risk factors were measured in 114 black patients undergoing cardiac catheterization for probable CAD. Patients (coronary narrowing of 50% or greater; n = 63) were compared to those without significant stenoses (n = 51). Total cholesterol and low-density lipoprotein cholesterol (LDLC) were both significantly associated with the presence of CAD in men and women; however, high-density lipoprotein cholesterol (HDLC) had discriminatory value only for women. The ratio of total cholesterol to HDLC (TC:HDL) separated patients from control subjects in both sexes, most efficiently among women, and was the only lipid variable associated with CAD in the age group over 55 years. Hypertension and angina were frequent in both groups and did not identify those with disease. In summary, LDLC was the best predictor among the lipids for men (likelihood ratio = 9.4) and TC:HDL was the best indicator of disease among women (likelihood ratio = 15.7). Low HDLC levels may, in part, account for the increased incidence of CAD among black women. Further population studies of factors leading to reduced HDLC, namely, obesity and diabetes, are needed. |
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