Wnt信号转导通路与细胞凋亡

细胞信号转导是各类信号通过细胞膜或细胞内信使分子引起基因表达或物质代谢改变的过程。因此,细胞信号转导过程发生障碍或异常,必然会导致细胞生长、分化、代谢及生物学行为异常,从而引起各种疾病甚至肿瘤。Wnt信号转导通路是一个由多种分子参与、相互影响、相互制约和协同作用的复杂体系;是胚胎发育、调控细胞生长增殖的关键途径。由于基因突变或稳定性增加引起该途径异常激活可以启动c-myc、cyclin、MMP-7、Survivin等下游靶基因表达异常,导致细胞增殖,抑制细胞凋亡,肿瘤形成等。Wnt信号通路作为细胞信号转导系统之一,参与肿瘤发生的机制涉及信号转导、细胞周期、细胞增殖、迁移和分化、细胞凋亡,介导细胞的黏附等多方面。

Wnt Signal Franscluction Pathway and Apoptosis

Cell signal transduction is the process which the various types of signal through the cell membrance or intracellular signal messenger molecule causing change in gene expression or metabolism.Thus,the cell signal transduction process occurs barrier or abnormal will inevitably lead to cell growth,differentiation,metabolism and biological behavior disorders,thereby can cause illness and ever cancer.Wnt signaling pathway is a variety of elements mutual influence and mutual restriction and synergies of the complex system;is the embryonic development regulation of cell growth and proliferation of the critical path.As the gene mutation or the stability to increase to cause this way exceptionally to activate may start c-myc,cyclin,MMP-7,survivin and other downstream target genes abnormal expression,leading to cell proliferation,inhibition of apoptosis,tumor.formationetc.Wnt signaling pathway as one of the cell signaling transduction system parcipate in the mechanism of tumorigenesis and play an important role in signal transduction,cell cycle,cell proliferation,migration and differentiation,apoptosis,cell adhesion mediated etc.