Anti-inflammatory activity of roots of Achyranthes aspera |
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| Authors: | S Vijaya Kumar P Sankar R Varatharajan |
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| Institution: | 1. School of Pharmacy, INTI International University College, Persiaran Perdana BBN, Putra Nilai, Nilai, Negeri Sembilan, Malaysiasvkumar1979@yahoo.com;3. Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India;4. School of Pharmacy, Masterskill College of Nursing &5. Health, Jalan Kemachaya, Cheras, Selangor Darul Ehsan, Malaysia |
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| Abstract: | This study investigated the anti-inflammatory potential of the alcohol extract of Achyranthes aspera Linn. (Amaranthaceae) in Wistar rats after oral administration (50, 100, and 200?mg/kg). This was done using the carrageenan-induced paw edema method (acute inflammatory model) and cotton pellet granuloma test (chronic inflammatory model). The alcohol extract showed significant suppressed granuloma formation. Collectively, these data demonstrate promising anti-inflammatory activity against both acute and chronic inflammation. In addition, inhibition of prostaglandins and bradykinins may play a role. This study revealing the promising anti-inflammatory activity of Achyranthes aspera roots has been carried out scientifically for the first time. |
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| Keywords: | Alcohol extract Achyranthes aspera (Amaranthaceae) anti-inflammatory activity roots |
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