Prevention of Carbon Tetrachloride-Induced Hepatotoxicity by the Ethanol Extract of Capparis moonii Fruits in Rats |
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Authors: | M. Ali Ramidi Ramachandram M.R.M. Rafiullah Onkar Singh A.W. Siddiqui S.R. Mir |
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Affiliation: | Phytochemistry Research Laboratory, Faculty of Pharmacy Jamia Hamdard University New Delhi India |
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Abstract: | The effect of the ethanol extract of Capparis moonii Hook. f. Thoms. (Capparidaceae) fruits was studied in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The hepatotoxicity was induced in rats with the administration of 1 : 1 (v/v) mixture of CCl4 in olive oil at the dose of 1 ml/kg subcutaneously on day 7. The ethanol extract of C. moonii (200 mg/kg) and the standard drug silymarin (25 mg/kg) were given orally from day 1 to day 9. The extract of C. moonii produced significant (p < 0.001) lowering of the elevated Serum glutamic oxaloacetic transaminace (SGOT) Serum glutamicpyraric transaminase (SGPT), alkaline phosphatase (ALP), and a rise of depleted total protein when compared with the toxic control. The results were comparable with the standard drug silymarin. |
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Keywords: | Antihepatotoxic Capparis Moonii Ccl4 Silymarin |
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